Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.1.1.3 (
HSD
)
3,464
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excess dietary carbohydrates are linked to dysregulation of metabolic pathways converging to mitochondria and metabolic inflexibility. Here, we determined the role of the mitochondrial pyruvate carrier (MPC) in the occurrence of this metabolic inflexibility in wild-type (WT) and
MPC1
-deficient (
MPC1
def
) flies that were exposed to diets with different sucrose concentrations for 15-25 days (Standard Diet: SD, Medium-Sucrose Diet: MSD, and High-Sucrose Diet:
HSD
). Our results showed that
MPC1
def
flies had lower mitochondrial respiration rates than WT flies on the SD and MSD. However, when exposed to the
HSD
, WT flies displayed decreased mitochondrial respiration rates compared to
MPC1
def
flies. WT flies exposed to the
HSD
also displayed increased proline contribution and slightly decreased
MPC1
expression. Surprisingly, when fed the MSD and the
HSD
, few metabolites were altered in WT flies whereas
MPC1
def
flies display significant accumulation of glycogen, glucose, fructose, lactate, and glycerol. Overall, this suggests that metabolic inflexibility starts to occur in WT flies after 15-25 days of exposure to the
HSD
whereas the
MPC1
def
flies display metabolic inflexibility independently of the diet provided. This study thus highlights the involvement of MPC as an essential protein in Drosophila to maintain proper metabolic homeostasis during changes in dietary resources.
...
PMID:Role of the Mitochondrial Pyruvate Carrier in the Occurrence of Metabolic Inflexibility in
Drosophila melanogaster
Exposed to Dietary Sucrose. 3306 85
