Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.1.1.21 (
aldose reductase
)
3,305
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
aldose reductase
0.871
aldehyde reductase
0.147
ALR2
0.057
Aldose reductase
0.045
sorbitol dehydrogenase
0.007
Aldehyde reductase
0.007
AKR1B1
0.006
aldo-keto reductase
0.006
AKR1A1
0.003
NADPH
0.002
NADP+
0.001
dihydrodiol dehydrogenase
0.001
chlordecone reductase
0.001
AFAR
0.001
ARI
0.001
AKR1B1 protein
0.001
NADPH-dependent carbonyl reductase
0.001
carbonyl reductase
0.001
aldehyde reductase I
0.001
SMIT
0.001
ALDR1
0.001
tonicity-responsive enhancer binding protein
0.001
AKR7A2
0.001
reductase
0.000
NADP
0.000
Sorbitol dehydrogenase
0.000
BGT1
0.000
GSTA5
0.000
SNK
0.000
TonEBP
0.000
AKR7A4
0.000
Tonicity-responsive enhancer binding protein
0.000
SCALD
0.000
KHK protein
0.000
beta-centractin
0.000
NFAT5 protein
0.000
fructokinase
0.000
NADH
0.000
STZ
0.000
ADP-ribosylation factor-like protein 2
0.000
more...
Disease
diabetic cataract
0.006
diabetic neuropathy
0.004
diabetes
0.001
hyperglycemia
0.001
diabetic retinopathy
0.001
cataract
0.001
galactosemia
0.001
retinopathy
0.000
lens opacity
0.000
neuropathy
0.000
diabetic nephropathy
0.000
Diabetic neuropathy
0.000
Cardiac autonomic neuropathy
0.000
Diabetic polyneuropathy
0.000
Osmotic nephrosis
0.000
Sensorimotor polyneuropathy
0.000
autonomic neuropathy
0.000
Armanni-Ebstein lesion
0.000
diabetic hyperglycemia
0.000
IDD
0.000
peripheral neuropathy
0.000
antidiuresis
0.000
renal disease
0.000
PARK3
0.000
hyperosmolality
0.000
background diabetic retinopathy
0.000
Diabetic autonomic neuropathy
0.000
Diabetic maculopathy
0.000
background retinopathy
0.000
GSH
0.000
Diabetic microangiopathy
0.000
Diabetic complications
0.000
polyneuropathy
0.000
Microangiopathy
0.000
blindness
0.000
type 2 diabetes
0.000
type 1 diabetes
0.000
Hers
0.000
Diabetic encephalopathy
0.000
cystic ovary
0.000
more...
Symptom
strangury
0.000
Blanching
0.000
Spots
0.000
inanition
0.000
presyncope
0.000
urethral discharge
0.000
polyuria
0.000
Halo
0.000
hyperesthesia
0.000
Anoxia
0.000
ketonuria
0.000
pain
0.000
numbness
0.000
cachexia
0.000
muscle cramps
0.000
DNA marker
0.000
polydipsia
0.000
eds
0.000
Hudson
0.000
functional recovery
0.000
paresthesia
0.000
tingling
0.000
fasciculation
0.000
Neuropathic pain
0.000
dizziness
0.000
menopausal symptoms
0.000
myalgia
0.000
blurred vision
0.000
tense
0.000
syncope
0.000
constipation
0.000
dry eye
0.000
dystonia
0.000
weakness
0.000
exhaustion
0.000
starvation
0.000
flushing
0.000
spasm
0.000
fatigue
0.000
nausea and vomiting
0.000
more...
Drug
Ponalrestat
0.012
Epalrestat
0.011
Fidarestat
0.007
Fidarestat
0.007
Alrestatin
0.004
Ranirestat
0.002
Zenarestat
0.002
Minalrestat
0.002
Alond
0.001
Lidorestat
0.000
Alredase
0.000
C13H19NO2
0.000
Myo-Inositol
0.000
NADH
0.000
Hexitol
0.000
Galactose
0.000
Bendazac
0.000
Lodoxamide tromethamine
0.000
Timiperone
0.000
Clinoril
0.000
Corydalis tuber
0.000
ICI
0.000
Fructose
0.000
Coconut oil
0.000
Aminoguanidine
0.000
Idebenone
0.000
ascorbate
0.000
Ouabain
0.000
AraC
0.000
lysine
0.000
Tween 40
0.000
Cibacron Blue
0.000
Glycyrrhiza
0.000
Gliclazide
0.000
Swertia
0.000
Desferal
0.000
Pyridoxal
0.000
TAT
0.000
Cellulose acetate
0.000
Desferal
0.000
more...
Enzyme
aldose reductase
0.999
aldehyde reductase
0.150
aldehyde reductase
0.139
aldehyde reductase
0.139
CPR
0.014
sorbitol dehydrogenase
0.013
alcohol dehydrogenase
0.008
mannitol dehydrogenase
0.007
carbonyl reductase
0.001
dihydrodiol dehydrogenase
0.001
prostaglandin F synthase
0.001
xylitol dehydrogenase
0.000
2,5-diketo-D-gluconate reductase
0.000
xylitol dehydrogenase
0.000
EC 1.1.99.22
0.000
3(17)alpha-hydroxysteroid dehydrogenase
0.000
GRase
0.000
D-xylonate dehydratase
0.000
ketohexokinase
0.000
dulcitol dehydrogenase
0.000
D-sorbitol dehydrogenase
0.000
xylonolactonase
0.000
3alpha-hydroxysteroid dehydrogenase
0.000
methylglyoxal reductase
0.000
L-glycol dehydrogenase
0.000
aldehyde dehydrogenase
0.000
aryl-alcohol dehydrogenase
0.000
aldehyde dehydrogenase
0.000
aldehyde dehydrogenase
0.000
xylulokinase
0.000
aldehyde dehydrogenase
0.000
L-arabinitol dehydrogenase
0.000
D-xylose dehydrogenase
0.000
arabitol dehydrogenase
0.000
macrocin O-methyltransferase
0.000
sepiapterin reductase
0.000
fructokinase
0.000
benzyl alcohol dehydrogenase
0.000
aldehyde dehydrogenase
0.000
fatty alcohol oxidase
0.000
more...
Compound
Sorbinil
0.032
Tolrestat
0.009
Zopolrestat
0.005
Sorbitol
0.003
NADPH
0.002
NADPH
0.002
2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
0.001
NADP
0.001
glucose
0.001
aldehyde
0.001
aldehyde
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.001
Byakangelicin
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.001
C13H12O5
0.000
galactose
0.000
C22H26N4O2
0.000
2,4-dimethyl-1,3-dioxane
0.000
C22H26N4O2
0.000
D-Xylonate
0.000
C13H13NO2
0.000
p-Nitrobenzaldehyde
0.000
C13H12O5
0.000
D-glucuronate
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
C13H19NO2
0.000
more...