Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.21 (aldose reductase)
 3,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
aldose reductase 2882
aldehyde reductase 485
NADPH 391
Aldose reductase 253
insulin 247
reductase 206
Sep 201
ALR2 191
sorbitol dehydrogenase 151
aldo-keto reductase 148
Mol 139
NADH 123
NADP 106
NADP+ 92
ATPase 83
GSH 73
NMR 67
NAD 66
AKR1B1 59
albumin 54
more...
Disease
diabetes 1062
hyperglycemia 290
cataract 236
diabetic neuropathy 225
neuropathy 160
diabetic retinopathy 129
retinopathy 122
cancer 99
renal disease 98
diabetic nephropathy 93
GSH 73
type 2 diabetes 66
diabetic cataract 66
peripheral neuropathy 49
ischemia 42
tumor 40
type 1 diabetes 39
galactosemia 38
atherosclerosis 36
blindness 35
more...
Symptom
pain 42
functional recovery 6
weakness 5
polyuria 5
numbness 5
dizziness 4
anesthesia 4
fatigue 4
cachexia 4
paresthesia 3
starvation 3
constipation 3
syncope 3
myalgia 3
Spots 2
dystonia 2
diarrhea 2
discomfort 2
presyncope 2
polydipsia 2
more...
Drug
NADH 123
Epalrestat 42
Ponalrestat 40
ICI 35
lysine 35
ascorbate 26
Fidarestat 25
Fidarestat 25
Galactose 22
Leaf 15
Alrestatin 15
ROS 13
Fructose 12
Gel 10
vitamin E 9
Ranirestat 8
Zenarestat 7
Ouabain 7
Cardiovasc 7
Indomethacin 6
more...
Enzyme
aldose reductase 3305
alcohol dehydrogenase 502
aldehyde reductase 501
aldehyde reductase 493
aldehyde reductase 486
CPR 486
sorbitol dehydrogenase 211
protein kinase C 112
ATPase 96
mannitol dehydrogenase 63
superoxide dismutase 56
mitogen-activated protein kinase 52
aldehyde dehydrogenase 45
aldehyde dehydrogenase 45
aldehyde dehydrogenase 44
aldehyde dehydrogenase 44
aldehyde dehydrogenase 44
catalase 44
glutathione peroxidase 41
carbonyl reductase 38
more...
Compound
glucose 894
NADPH 393
NADPH 391
galactose 332
Dec 218
aldehyde 218
aldehyde 211
NADP 199
sodium 187
water 163
oxygen 162
phosphate 132
Clin 131
NADH 123
DNA 123
Sorbinil 122
acetic acid 106
NAD 100
hydrogen 97
Sorbitol 93
more...