Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.105 (MDR)
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Human Gene/Protein
retinol dehydrogenase 12.8
HSD9 12.8
NADP-dependent retinol dehydrogenase/reductase 12.8
NG-TRA 11.8
Retinol dehydrogenase 11.8
SCALD 11.8
RODH 11.8
NRSN1 11.5
RDH11 11.4
FPTB 11.2
SDR9C4 11.2
HLA-B associated transcript 3 11.2
DNB1 11.2
RDHE2 11.2
RDH1 11.0
RDH5 11.0
NRDR 10.9
RDH8 10.6
retinol dehydrogenase 10 10.6
MRP-1 10.5
Retinol dehydrogenase 13 10.5
Transgelin 2 10.5
RDH12 10.5
TOP2 beta 10.5
MRPS27 10.2
short-chain dehydrogenase/reductase 1 10.2
PABP4 10.2
DHRS9 10.1
KAZ 10.0
RDHL 10.0
ornithine decarboxylase antizyme 2 10.0
MCEE 9.8
SLC16A14 9.8
retSDR1 9.8
L36A 9.8
DHRS4 9.8
inhA 9.8
Retinol dehydrogenase 12 9.6
ROAT1 9.6
TAP-like 9.6
Laminin subunit beta-3 9.6
LRP protein 9.6
semaphorin E 9.6
Glutamate decarboxylase 1 9.5
HCAP 9.5
collagen alpha-2 9.5
retinal dehydrogenase 2 9.4
FN3K-related protein 9.4
MTB 9.3
MRP 9.2
short chain dehydrogenase/reductase 9.2
MDP1 9.1
RU2 9.1
CD3EAP 9.1
SLC2A14 9.1
Rgr 9.1
multidrug resistance associated protein 9.0
MDR protein 9.0
stoned B 9.0
GALNT11 9.0
rgr 9.0
GNLY 9.0
P-gp 9.0
PGLYRP2 8.9
BCRP1 8.9
RDR 8.8
retinol dehydrogenase 5 8.8
mdr1 8.8
MRP7 8.8
MDR1 8.7
OAT7 8.7
Fructosamine-3-kinase 8.7
CAMK2G 8.7
endophilin A2 8.7
SIT1 8.7
SLC27A2 8.6
PARP4 8.6
SRD5A1 8.6
3alpha-HSD 8.6
CTNNAL1 8.6
more...
Disease
CNS ventriculitis 12.8
Multidrug resistant tuberculosis 12.2
Drug resistant tuberculosis 10.9
Fundus albipunctatus 10.8
epituberculosis 10.5
LCA3 9.6
FWT1 8.7
Acinetobacter infection 8.5
Mammary adenocarcinoma 8.5
Diabetic foot infection 8.4
WT3 8.2
AD10 8.1
FAB M0 8.1
Poncet's disease 8.0
VRSA 7.8
PDR 7.7
Congenital tuberculosis 7.5
Ventilator associated pneumonia 7.5
Metastatic malignant melanoma 7.4
Mycobacterium kansasii infection 7.3
hemeralopia 7.3
Pancreatic Ductal Adenocarcinoma 7.2
Pancreatic Ductal Adenocarcinoma 7.2
Erythroleukemia 7.2
KPC 7.2
tuberculosis 7.1
AUTS2 7.1
Aspergilloma 7.0
VIN 7.0
IFD 6.9
Hot spots 6.8
Myxoid liposarcoma 6.8
Jensen 6.7
generalized tuberculosis 6.7
USH1C 6.6
lymphangioleiomyomatosis 6.5
large cell lung cancer 6.5
Klebsiella pneumoniae infection 6.4
Mycobacterium 6.4
Pott's disease 6.4
secondary AML 6.4
MRD 6.4
childhood rhabdomyosarcoma 6.2
proliferative diabetic retinopathy 6.1
adenocarcinoma of unknown primary 6.0
Candidemia 5.9
anomie 5.9
Traveler's diarrhea 5.9
Enzyme inhibition 5.8
CTX 5.8
pulmonary tuberculosis 5.8
CEM 5.7
ovarian serous cystadenocarcinoma 5.7
clear cell sarcoma of the kidney 5.6
Lymphocytic infiltration 5.6
MRSA 5.5
VES 5.5
metastatic neuroblastoma 5.4
extrapulmonary tuberculosis 5.4
paratyphoid fever 5.4
ST8 5.4
pediatric AML 5.4
Kaposi's Sarcoma 5.3
Bovine tuberculosis 5.3
night blindness 5.3
chronic phase CML 5.3
RAEB-T 5.3
PER 5.2
Gram-negative bacteremia 5.2
LWS 5.2
Diaz 5.1
osteoblastic osteosarcoma 5.1
Delhi 5.0
Dubin-Johnson syndrome 5.0
Klatskin 5.0
Ototoxicity 5.0
uterine sarcoma 5.0
MDM 5.0
AD1 4.9
typhoid 4.9
more...
Symptom
Crushing 5.9
skin irritant 5.3
productive cough 4.7
emaciation 3.8
POA 3.8
Gastrointestinal symptoms 3.6
rales 3.5
chest tightness 3.2
hemoptysis 3.0
otalgia 2.8
abnormal gait 2.7
night sweats 2.6
tingling 2.5
ENT 2.0
incoordination 2.0
chronic cough 1.8
stigma 1.7
arthralgia 1.6
nausea and vomiting 1.6
nausea 1.5
Wind 1.5
asthenia 1.4
HSA 1.3
dizziness 1.2
constipation 1.1
Ill 1.0
cough 0.9
apathy 0.8
diarrhea 0.7
collapse 0.6
paresthesia 0.5
numbness 0.5
lethargy 0.3
hepatomegaly 0.3
starvation 0.2
flushing 0.2
tinnitus 0.1
anorexia 0.1
acidity -0.1
vomiting -0.1
seizures -0.2
syncope -0.4
respiratory distress -0.4
insomnia -0.6
discomfort -0.6
back pain -0.7
discomfort -0.8
weakness -0.8
erythema -0.9
overweight -0.9
ataxia -1.1
hypothermia -1.3
dyspnea -2.0
headache -2.0
abdominal pain -2.1
pain -2.6
fatigue -2.8
Drug
Exatecan mesylate 11.8
Capreomycin sulfate 11.2
Colistimethate 10.5
Ilmofosine 9.1
Tetrofosmin 8.9
VCR 8.5
all-trans-retinol 8.5
EMB 8.1
ADR 8.1
Isoniazid 7.9
Colistin 7.7
KAN 7.7
CPFX 7.5
VCR 7.3
AMK 7.3
Span 40 7.2
CXM 7.1
LVFX 6.9
OFLX 6.9
Sitafloxacin 6.9
Idarubicin 6.7
Tipifarnib 6.7
CPFX 6.6
Gramicidin D 6.5
Ixabepilone 6.4
Ertapenem 6.4
CAZ 6.4
Gatifloxacin 6.3
Moxifloxacin 6.3
Zinc sulfate 6.3
Zinc sulfate 6.3
Novantrone 6.2
ABC 6.1
Trilostane 6.0
Ofloxacin 6.0
TPV 5.9
Miltefosine 5.9
CTX 5.9
Dalbavancin 5.9
Compound 15 5.9
CTX 5.9
Check 5.8
Compound 9 5.8
Axitinib 5.8
Ceftazidime 5.7
Trabectedin 5.6
Meropenem 5.6
Adriamycin 5.5
CFX 5.5
Meropenem 5.5
Retinoic acid 5.5
3-Methyladenine 5.4
Isotretinoin 5.4
Vitamin A 5.4
Navelbine 5.3
BCG vaccine 5.3
Retinoic Acid 5.3
Carbenoxolone 5.2
Tween 40 5.2
Mitomycin-C 5.1
Poloxamer 5.1
MDM 5.1
Rifaximin 5.1
Cremophor EL 5.1
ADM 5.1
CPT-11 5.1
IPM 5.1
CTX 5.0
Peridex 4.9
Glucantime 4.9
Emodin 4.9
Primaquine 4.9
Taxol 4.9
Anakinra 4.8
MTC 4.8
TEL 4.8
Pregnenolone 4.6
Emodin 4.6
CPM 4.6
RFP 4.6
more...
Enzyme
MDR 12.8
retinal oxidase 10.7
retinal dehydrogenase 10.4
retinol isomerase 9.9
lecithin-retinol acyltransferase 9.6
retinol acyltransferase 8.8
retinyl ester hydrolase 8.8
aldehyde reductase 8.8
carotene 15,15'-dioxygenase 8.3
P-glycoprotein 8.3
lecithin:retinol acyltransferase 8.3
3alpha-hydroxysteroid dehydrogenase 7.6
enoyl-ACP reductase 7.0
enoyl-ACP reductase 7.0
6beta-hydroxylase 6.8
2,3-butanediol dehydrogenase 6.7
ADH3 6.4
hydroxyprostaglandin dehydrogenase 6.2
HDR 6.2
17beta-HSD 6.2
2,4-dienoyl-CoA reductase 6.1
nicotinamidase 6.0
transcarboxylase 6.0
shikimate kinase 6.0
PRPP synthetase 5.9
matriptase 5.8
shikimate dehydrogenase 5.6
MTD 5.6
APS reductase 5.5
topoisomerase 5.5
lanosterol 14alpha-demethylase 5.5
topoisomerase 5.5
aldehyde reductase 5.4
17beta-HSD 5.4
CAO 5.4
HIV-1 protease 5.4
aldehyde reductase 5.4
NAO 5.3
ALDH 5.3
CDR 5.2
chymopapain 5.1
alcohol dehydrogenase 5.1
chymopapain 5.1
dihydrodiol dehydrogenase 5.0
deoxycytidine kinase 4.9
sphingomyelin synthase 4.9
glucosylceramide synthase 4.9
formaldehyde dehydrogenase 4.9
NCP 4.9
peptide deformylase 4.9
carbonyl reductase 4.8
CYP3A4 4.7
3beta-hydroxysteroid dehydrogenase 4.5
cysteine synthase 4.5
alanine racemase 4.5
4CL 4.5
CPM 4.4
AOR 4.4
trypanothione reductase 4.3
ATP sulfurylase 4.3
glycolate oxidase 4.3
aldehyde oxidase 4.3
nicotinamide phosphoribosyltransferase 4.3
ADH 4.3
beta-hydroxybutyrate dehydrogenase 4.3
rhodopsin kinase 4.2
AGT 4.2
beta-lactamase 4.1
aldehyde dehydrogenase 4.0
aldehyde dehydrogenase 4.0
aldehyde dehydrogenase 4.0
aldehyde dehydrogenase 3.9
caspase-6 3.9
lysostaphin 3.9
caspase-6 3.9
farnesyltransferase 3.8
5alpha-reductase 3.8
5alpha-reductase 3.8
aldehyde dehydrogenase 3.7
thiopurine methyltransferase 3.7
more...
Compound
1,3-dichloro-2-methylbenzene 12.8
MDR 12.6
Capreomycin sulfate 11.8
9-cis-retinol 11.4
bicyclo[2.2.1]heptan-2-one 10.8
Androstanol 10.8
Mitraphylline 10.5
Capreomycin 10.3
3,4,5-Trimethoxycinnamic acid 10.2
Tuberostemonine 10.2
A 139 10.0
PMDT 10.0
bicyclo[2.2.1]heptan-2-one 9.8
R207910 9.7
Uvaol 9.6
2,4-dichlorobenzoic acid 9.5
Thaliblastine 9.5
SDZ PSC 833 9.5
Chloroacetanilide 9.4
Cyclotene 9.4
benzo[a]phenazine 9.4
6H-indolo[2,3-b]quinoxaline 9.4
Mitox 9.4
1H-pyrazole-1-carbothioamide 8.9
6-Chloropurine 8.8
Ethionamide 8.8
ATEC 8.8
Niguldipine 8.6
Clofazimine 8.5
Tryptanthrin 8.4
Pyrazinamide 8.4
Ethambutol 8.4
CaBr2 8.2
INH 8.1
Rhodamine 123 8.0
Acetylshikonin 8.0
Difloxacin 7.8
4-methyl-1,2,3-thiadiazole 7.8
Merbarone 7.8
11-cis-retinal 7.7
Acridone 7.7
9-cis-Retinoic acid 7.7
Tigecycline 7.6
MHT 7.6
MK 571 7.4
D-Cycloserine 7.3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 7.3
Ural 7.3
Vitamin K epoxide 7.3
9,10-dihydroacridine 7.2
undecanal 7.2
undecanal 7.1
Rifampicin 7.1
Decursin 7.1
Lapachol 7.1
4-Methylpyrazole 7.1
Rifabutin 7.1
Ziram 7.1
Linezolid 7.0
Resazurin 6.9
H-69 6.9
Sitafloxacin 6.9
DMDP 6.9
Toremifene 6.9
Mitragynine 6.9
HPTE 6.9
Diosmetin 6.9
Zaleplon 6.8
SbCl3 6.8
Acetochlor 6.8
3-quinolinecarboxylic acid 6.8
ADR 6.7
Rifamycin 6.7
gamma-Glutamylcysteine 6.7
EPB 6.7
1,2,5-oxadiazole 6.7
Dettol 6.7
thieno[2,3-b]pyridine 6.7
Nedaplatin 6.6
Triadimefon 6.6
more...