Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.1.1.1 (
alcohol dehydrogenase
)
9,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Suncus murinus (suncus) is an animal species highly sensitive to ethanol (Lin, S.-C., Saito, H., Yohro, T. and
Shiga
, J.,J. Toxicol. Env. Health, 18: 575-587, 1986). To elucidate the mechanism involved in sensitivity to alcohol, we investigated that properties of
alcohol dehydrogenase
(
ADH
) and aldehyde dehydrogenase (ALDH) in the suncus in comparison with the rat. The activities of ALDH in microsomes and mitochondria of suncus livers were lower than those in rat livers, although the activity of cytosolic
ADH
was not different between the suncus and the rat. We propose that the high sensitivity of the suncus to alcohol can be accounted for, at least in part, by the low activity of ALDH in suncus liver.
...
PMID:Low activity of aldehyde dehydrogenase (ALDH) in liver of Suncus murinus: possible explanation for high sensitivity to alcohol. 919 8
