Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.1 (alcohol dehydrogenase)
 9,284 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Liver is the main organ associated with alcohol oxidation. The definite liver enzymes role is not elucidated as yet, that participates in alcohol metabolism. The nutrient factors are of a great importance for the development of the alcoholic liver lesions and for the induction of liver enzymes under alcohol effect. Alcohol effect was studied in 80 male albino rats, Wistar strain, as well as some nutritional diets upon microsomal enzymes--cytochrome P-450, aniline-hydroxilase aminopyrine-demetilase., ADH and DALA-C. The changes, developed in the body weight are discussed as well as the liver weight and the microsomal protein under alcohol effect and the respective nutritional regimens. Alcohol, given in a dose of 4g/kg body weight, in the course of 60 days, induces but slightly the microsomal enzymes cytochrome P-450 and aniline-hydroxilase and does not induce aminopyrine-demetilase. ADH activity decrease with the chronic alcohol loading. Mitochondrial enzyme DALA-C is moderately induced by alcohol. Lipid and protein role is decisive in the induction process while the carbohydrate role is less.
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PMID:[Effect of alcohol and diet on some liver enzymes]. 118 92

This study examined metabolic interactions between two nutrients--ethanol and carbohydrate. Both nutrients are metabolized by a common pathway to fatty acids from acetyl-coenzyme A by lipogenic enzymes. The effects of ethanol and carbohydrate on the induction of lipogenic enzymes in livers of rats were examined using two types of base diets differing in carbohydrate and lipid content and using isocaloric substitutions of ethanol, carbohydrate, and fat. Three nonlipogenic enzymes were used for comparison. Isocaloric substitution of both fat and carbohydrate for ethanol was necessary to show the specific effects of alcohol on the activity of lipogenic or nonlipogenic enzymes. Carbohydrate, and not ethanol, induced lipogenic enzymes. Ethanol specifically reduced the activity of lactate dehydrogenase and malic enzyme, but did not affect those of alcohol dehydrogenase or glycerol 3-phosphate dehydrogenase. Ethanol interacted with carbohydrate to increase the activity of ATP citrate lyase. In addition, we studied the effects of ethanol and different kinds of carbohydrates on the growth of rats and on the morphology of their livers and intestines. Ethanol significantly decreased growth characteristics (weight gain, growth rate, and caloric efficiency). Fructose, either as a monosaccharide or in sucrose, decreased this alcohol effect. Sucrose was better than glucose in lowering lipid accumulation in livers of rats. Fragility of intestinal villi was found with an alcohol, low carbohydrate diet, but was not present in alcohol diets with a higher level of carbohydrate. In contrast to carbohydrate, ethanol lacked some characteristics of a nutrient, namely, it did not induce some enzymes involved in its metabolism and did not promote optimum growth.
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PMID:Alcohol as a nutrient: interactions between ethanol and carbohydrate. 217 66