Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: DrugBank:EXPT03141 (L-tyrosine)
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Human Gene/Protein
PRAMEF12 13.7
GRAMD1C 12.7
FETA 12.1
DCAKD 12.1
tyrosine 3-monooxygenase 11.9
NUPL1 11.7
pancreatopeptidase E 11.4
DTD1 11.4
EPS8L3 11.4
HSDL2 11.1
4a-carbinolamine dehydratase 11.0
SNRPD3 10.7
LCAP 10.4
LIN7C 10.3
phenylalanine-tRNA synthetase 10.1
PAT3 10.1
homogentisate dioxygenase 10.0
mrg 9.9
Tyrosine aminotransferase 9.8
TPH2 protein 9.8
DCoH 9.6
endofin 9.5
CAS2 9.4
iodotyrosine deiodinase 9.4
Phenylalanine hydroxylase 9.3
SOX12 9.3
GFRP 9.3
CACNA1I 9.3
TyrRS 9.2
maleylacetoacetate isomerase 9.2
BAG5 9.1
Tyrosinase 9.0
CTRB1 9.0
tubulin-tyrosine ligase 9.0
NRG2 8.8
tyrosyl-tRNA synthetase 8.7
dopachrome tautomerase 8.7
Carboxypeptidase A 8.6
tyrosinase-like 8.6
MNT 8.6
tyrosinase 8.6
p-hydroxyphenylpyruvate dioxygenase 8.5
gastricsin 8.5
LMW-PTP 8.5
thyroid protein 8.5
ATA2 8.4
golgin-245 8.4
AAT1 8.4
LAT1 8.4
phenylalanine hydroxylase 8.3
TYR 8.3
C1 esterase 8.3
PAPA 8.3
L-type amino acid transporter 1 8.2
MST4 8.2
TRP2 8.2
phenylalanine 4-monooxygenase 8.2
Cep135 8.1
MAP4K3 8.1
SLC30A10 8.1
PAT2 8.1
C-MET 8.0
BI-1 8.0
SLC7A5 8.0
ddc 8.0
tyrosinase-related protein-1 8.0
pepsinogen C 7.9
4-hydroxyphenylpyruvate dioxygenase 7.9
histidine ammonia-lyase 7.9
TA4 7.9
BCH 7.8
D-X 7.7
RBM15 7.7
CHN2 7.6
dopa decarboxylase 7.6
protein-tyrosine-phosphatase 7.6
DnaJ-like 7.6
PAT1 7.6
TRP-1 7.5
PTPase 7.5
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Disease
Richner-Hanhart syndrome 10.4
acute lymphadenitis 8.8
tyrosinosis 8.5
chronic lymphadenitis 8.5
Hanhart 8.4
demineralization of bone 8.4
Nemaline myopathy 8.3
tyrosinemia 8.3
PAPA 8.0
RAT 8.0
melanoderma 8.0
Vernet 7.7
Bone marrow depression 7.6
Tic 7.1
AAT1 6.9
BCH 6.8
Angiostrongylus costaricensis 6.7
phenylketonuria 6.6
amphetamine abuse 6.6
amelanotic melanoma 6.6
seasonal rhinitis 6.5
hyperphenylalaninemia 6.5
NSD 6.4
Maedi 6.2
Sendai virus infection 6.1
dyschromia 6.1
Phenylketonuria 6.0
melasma 6.0
AIDS/HIV 6.0
vascular dilation 6.0
HTX 6.0
PAL 5.9
HTX 5.9
IMT 5.8
Enzyme inhibition 5.7
hormone refractory prostate cancer 5.4
CLE 5.4
CLE 5.4
malignant state 5.3
freckles 5.3
tic 5.3
gastric retention 5.2
stage IV melanoma 5.1
acute tonsillitis 5.1
lentigo 5.0
attention deficit disorder 5.0
ST3 4.9
furunculosis 4.9
mastocytoma 4.9
ASAT 4.9
chronic tonsillitis 4.9
VPI 4.9
familial dysautonomia 4.9
hay fever 4.9
Alkaptonuria 4.9
MPE 4.9
CP1 4.9
HCA 4.8
maple syrup urine disease 4.8
pediatric brain tumor 4.7
GCE 4.7
HPP 4.6
HPP 4.5
AIP 4.5
Erysipelothrix 4.5
AIP 4.4
Farber 4.4
Erysipelothrix 4.4
RDC 4.4
Goldblatt 4.3
TMD 4.3
hyperprolactinemia 4.3
localized infection 4.3
anguish 4.2
severe mental retardation 4.2
Acute liver failure 4.2
PKS 4.2
OHD 4.2
multinodular goiter 4.1
Goldstein 4.1
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Symptom
physical symptom 5.8
hyperemesis gravidarum 4.6
drooling 4.3
bitter taste 3.3
HSA 3.2
dystonia 3.0
skin irritation 2.6
analgesia 2.4
agitation 2.2
starvation 2.1
acute pain 1.8
apathy 1.7
acidity 1.4
lethargy 1.2
tremor 1.1
sleepiness 1.1
distraction 0.5
weakness 0.5
nausea and vomiting 0.5
erythema 0.0
anorexia -0.0
respiratory distress -0.5
nausea -0.8
seizures -1.0
collapse -1.1
vomiting -1.2
anesthesia -1.5
pain -2.3
Drug
L-tyrosine 13.7
Methyldopate 12.1
Nardil 10.4
Benzoin 9.5
Calcium acetate 9.3
Aldomet 9.1
Calcium acetate 9.0
Aggrastat 8.3
Synthroid 8.0
Benserazide 8.0
3,4-Dihydroxyphenylalanine 7.4
Synthroid 7.3
Pyridostigmine bromide 7.3
Fosphenytoin 7.2
Sodium acetate 7.0
L-Ser 6.9
pyridoxal phosphate 6.8
BH4 6.6
Methyldopa 6.4
Navelbine 6.2
CrCl3 6.2
KCL 5.6
Bestatin 5.5
Palmitoyl 5.5
DFP 5.4
Copaxone 5.4
TAT 5.1
Vinorelbine 5.0
Pronase 5.0
Pregabalin 4.9
Aprotinin 4.9
DEX 4.9
Maltose 4.9
lysine 4.8
Citric acid 4.7
balanced salt solution 4.7
Papain 4.6
Salicylate 4.6
PPA 4.5
CEC 4.5
Digenea 4.5
Tocopherol 4.3
OTC 4.2
Captopril 4.1
Allergen 4.1
citric acid 4.0
Gabapentin 3.9
THA 3.9
GRF 3.8
Reserpine 3.8
ascorbate 3.7
-deoxyadenosine 3.7
Galactose 3.7
OTC 3.7
G418 3.6
Aloe 3.5
CoCl2 3.4
CoCl2 3.4
CaCl2 3.4
CaCl2 3.4
Methylene blue 3.4
Fraction 3.4
CCL 3.4
ZnCl2 3.4
ZnCl2 3.4
CaCl2 3.4
Glutathione 3.3
FeCl3 3.3
Alanine 3.3
NH3 3.3
Ginseng 3.0
Asn 3.0
HCH 3.0
PTC 2.9
FAD 2.9
DNase I 2.7
Gel 2.7
Biopolymers 2.7
ACT 2.6
NADH 2.6
more...
Enzyme
EC 2.1.1.29 13.7
cathepsin T 12.4
arogenate dehydrogenase 12.3
arogenate dehydratase 12.1
indolepyruvate C-methyltransferase 12.1
tyrosine phenol-lyase 11.8
EC 2.3.1.110 11.7
prephenate dehydrogenase 11.5
4'-OMT 11.4
prephenate dehydrogenase 11.3
pterin-4alpha-carbinolamine dehydratase 11.1
prephenate dehydratase 11.0
L-phenylalanine oxidase 10.8
thiohydroximate S-glucosyltransferase 10.5
DAHP synthase 10.4
aromatic amino acid aminotransferase 10.2
tyrosine decarboxylase 10.1
YdiB 9.7
chorismate mutase 9.6
maleylacetoacetate isomerase 9.6
phenol oxidase 9.6
phenylacetaldehyde dehydrogenase 9.5
leucine dehydrogenase 9.1
PabB 9.0
bothropasin 9.0
catechol oxidase 8.9
tubulin-tyrosine ligase 8.8
gastricsin 8.7
C1 esterase 8.6
tyrosine aminotransferase 8.6
CYP79A1 8.5
shikimate kinase 8.5
cucumisin 8.5
tyrosinase 8.4
phosphoamidase 8.4
phenylalanine hydroxylase 8.4
tryptophan aminotransferase 8.4
tubulin carboxypeptidase 8.3
long-chain acyl-coenzyme A dehydrogenase 8.3
fibrolase 8.3
D-amino acid aminotransferase 8.3
prozyme 8.3
4-hydroxyphenylpyruvate dioxygenase 8.2
homoprotocatechuate 2,3-dioxygenase 8.2
p-cresol methylhydroxylase 8.2
homogentisate 1,2-dioxygenase 8.1
CBPP 8.1
maleylacetate reductase 8.1
shikimate dehydrogenase 8.1
desulfhydrase 8.0
lysine 2,3-aminomutase 8.0
aromatic L-amino acid decarboxylase 8.0
3-dehydroquinate 7.9
carboxypeptidase A 7.8
T-protein 7.7
phosphoenolpyruvate synthase 7.7
DOPA decarboxylase 7.6
anthranilate synthase 7.6
cyclohydrolase 7.5
adamalysin 7.4
benzoylformate decarboxylase 7.4
proteinase A 7.2
proteinase A 7.2
biotin synthase 7.1
cinnamate 4-hydroxylase 7.1
tyrosine hydroxylase 7.0
4CL 7.0
chymotrypsin 6.9
PAL 6.8
phenylethanolamine N-methyltransferase 6.8
PTPase 6.7
oligopeptidase B 6.7
hatching enzyme 6.7
dihydropteridine reductase 6.6
prolinase 6.6
DCF 6.6
glycine decarboxylase 6.6
fumarylacetoacetate hydrolase 6.5
D-amino-acid oxidase 6.5
alanine racemase 6.4
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Compound
Normethadone 13.7
Pretyrosine 13.1
Macarpine 12.7
2,2-diphenylpentanoic acid 12.7
3-Nitro-L-tyrosine 12.7
C14H20O2 12.7
2-amino-3-phenylbutanoic acid 12.7
N-Acetyl-L-tyrosine 12.3
C7H9NO 11.7
Methyl p-hydroxycinnamate 11.7
5-amino-2-methylbenzenesulfonamide 11.7
6,7-dimethyl-5,6,7,8-tetrahydropteridine 11.4
L-Phenylalanine, 11.3
1-aminocyclohexanecarboxylic acid 11.3
Prephenate 11.2
2,4-dihydroxyphenylalanine 11.1
C15H10O2 10.9
Methanofuran 10.7
C15H14O3 10.7
Indole-3-pyruvic acid 10.5
o-Tyrosine 10.5
4-(2-aminoethyl)phenol 10.5
methyl 4-methoxybenzoate 10.5
3-hydroxyphenylalanine 10.5
3-hydroxyphenylalanine 10.5
3-hydroxyphenylalanine 10.5
3-hydroxyphenylalanine 10.5
L-Phenylalanine, 10.4
3-hydroxy-4-methoxybenzaldehyde 10.4
Cupferron 10.4
3,4-AHBA 10.4
1-azaspiro[4.5]decane 10.4
4-amino-3-hydroxybenzoic acid 10.4
o-Tyrosine 10.4
Thyronine 10.3
3-hydroxy-3-phenylpropanoic acid 10.3
4-hydroxyphenylpyruvate 10.2
Dityrosine 10.1
Dhurrin 10.1
Saframycin A 10.1
Diiodothyronine 10.1
4-methylphenylalanine 10.0
D-Phenylalanine 10.0
Nardil 9.9
Aloesin 9.9
DHICA 9.8
N-Hydroxy-2-acetylaminofluorene 9.7
HPLA 9.7
Bulbocapnine 9.7
Tyrocidine 9.6
Methidathion 9.6
EPNP 9.6
3-hydroxy-4-methoxybenzaldehyde 9.5
Maleylacetate 9.5
Benzoin 9.5
2-Nitrophenol 9.4
2-allylphenol 9.4
C5H5NO 9.4
2-iodobenzoic acid 9.4
Pyridine N-oxide 9.4
1,12-dodecanediamine 9.3
Phenylpyruvate 9.3
Pinosylvin 9.3
Pinosylvin 9.3
1-Anilinonaphthalene 9.3
Saccharopine 9.3
Pterin 9.3
6R-BH4 9.3
L-dopachrome 9.3
Cuminaldehyde 9.1
1-aminocyclopentanecarboxylic acid 9.1
1-aminocyclopentanecarboxylic acid 9.1
Homogentisate 9.1
1,4-phthalazinedione 9.1
4-phenoxyphenol 9.0
Kyotorphin 9.0
3-(2-naphthyl)alanine 9.0
ethyl phenylacetate 9.0
Coniferyl alcohol 9.0
DAHP 8.9
more...