Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: DrugBank:EXPT03113 (
Tryptophane
)
32
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
L-
tryptophan
is produced at the AMINO GmbH (Frellstedt, FRG) via biocatalytical condensation of the amino acid L-serine with indole. As a biocatalyst, tryptophan synthetase is used which is produced in high activities by a natural mutant Escherichia coli strain. The enzyme mechanism and specificity and the individual process-parameters for the biotransformation procedure are explained as well as the purification process of educts and products. This includes a detailed description of the quality control of educts, intermediates and final product. The active ingredient L-
tryptophan
is subsequently used by AMINO's subsidiary company esparma GmbH to produce and distribute the pharmaceutical
Lyphan
. The quality management system and the production procedure for
Lyphan
are described and discussed.
...
PMID:From sugar beet molasses to Lyphan. Integrated quality management from the raw material to the drug. 1072 Oct 87
