Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:EXPT03052 (THF)
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Human Gene/Protein
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 11.9
tetrahydrofolate dehydrogenase/cyclohydrolase 11.6
MTHFD2L 11.2
dihydrofolate reductase-like 1 10.9
Type II adenylyl cyclase 10.9
Serine hydroxymethyltransferase 10.9
AMT protein 10.9
cytosolic serine hydroxymethyltransferase 10.6
C1-tetrahydrofolate synthase 10.6
Formiminotransferase-cyclodeaminase 10.6
10-formyltetrahydrofolate dehydrogenase 10.6
C1orf69 10.3
Glycine synthase 10.3
SAF-2 10.3
Cytosolic serine hydroxymethyltransferase 10.3
Aminomethyltransferase 10.3
formyltetrahydrofolate dehydrogenase 10.3
dimethylglycine dehydrogenase 10.2
aminomethyltransferase 9.9
DIPP 9.9
ALDH1L2 9.8
methylenetetrahydrofolate dehydrogenase 9.6
dihydrofolate reductase-like protein 1 9.6
serine hydroxymethyltransferase 9.5
formyltetrahydrofolate synthetase 9.4
indolethylamine N-methyltransferase 9.3
CMH2 9.3
Glycinamide ribonucleotide formyltransferase 9.3
Formyltetrahydrofolate synthetase 9.3
sarcosine dehydrogenase 9.3
Dihydrofolate reductase 9.3
SHMT 9.2
SLC25A32 9.2
folylpolyglutamate synthetase 9.2
GAR transformylase 9.2
cytoplasmic serine hydroxymethyltransferase 9.1
SRP40 9.1
H-protein 9.1
folylpoly-gamma-glutamate synthetase 9.1
mitochondrial serine hydroxymethyltransferase 9.1
SHMT2 9.0
methylenetetrahydrofolate dehydrogenase 2 8.9
methylenetetrahydrofolate dehydrogenase 1 8.8
methionine synthase 8.8
Reduced folate carrier 8.8
GRL 8.8
PPCD 8.6
Exp7 8.6
ALDH1L1 8.5
folate-binding protein 8.5
TSase 8.5
mu4 8.4
glycinamide ribonucleotide formyltransferase 8.4
SHMT1 8.4
methionine synthase reductase 8.3
MTHFD1L 8.2
serine hydroxymethyltransferase 1 8.2
CHC 8.2
INMT 8.1
thymidylate synthetase 8.1
MTHFD1 8.0
HC6 8.0
5-methyltetrahydrofolate-homocysteine methyltransferase 8.0
CLEC10A 7.9
UBE2F 7.9
MTHFD2 7.9
TPAP 7.9
reduced folate carrier 7.9
COT 7.9
RNH2 7.8
N2N 7.8
GTPBP3 7.8
HECTD1 7.8
purH 7.8
transmembrane transport protein 7.8
thymidylate synthase 7.7
glycine decarboxylase 7.7
FTCD 7.6
FDH 7.5
serine hydroxymethyltransferase 2 7.5
more...
Disease
CMH2 10.3
Gurrieri syndrome 10.3
R-binder deficiency 10.3
Factor II mutation 9.9
methionine synthase deficiency 9.5
FH3 8.5
hydroxyprolinemia 8.3
transcobalamin II deficiency 8.2
ABPE 7.9
HPA1 7.5
vitamin B deficiency 7.4
DHPR deficiency 7.4
folate deficiency 7.3
folate deficiency anemia 7.2
Primary Sjogren's syndrome 7.2
cblF 7.1
PPCD 7.0
PCH2 6.9
CBS deficiency 6.9
OOCH 6.8
MGA3 6.7
Subacute combined degeneration 6.7
NNH 6.7
DMAC 6.6
DMAT 6.5
LDA 6.5
homocystinemia 6.5
NHC 6.5
homocystinuria 6.4
FDH 6.4
hyperglycinemia 6.4
megaloblastic anemia 6.3
hyperhomocysteinemia 6.3
Androgen excess 6.2
CHN 5.9
vitamin B12 deficiency 5.9
Protein S deficiency 5.8
Thrombophilia 5.8
retinal vein thrombosis 5.7
FADS 5.6
basal ganglia disease 5.6
NDI 5.5
NF2 5.4
TBS 5.4
Condensation 5.4
Retinal vein occlusion 5.4
11 beta-hydroxylase deficiency 5.4
hyperprolinemia 5.4
Salmonella bacteremia 5.3
Oral ulcers 5.2
ICT 5.2
CHR 5.1
FHF 5.1
choline deficiency 5.1
orotic aciduria 5.0
Multiple chemical sensitivity 5.0
DBM 5.0
hypoaldosteronism 4.9
POH 4.8
idiopathic dilated cardiomyopathy 4.7
mouse leukemia L1210 4.7
MCD 4.7
STY 4.6
hyperargininemia 4.6
LYP 4.5
Pulmonary thromboembolism 4.5
mesenteric thrombosis 4.5
NBS 4.5
pernicious anemia 4.5
Alpers 4.5
HBT 4.4
DBA2 4.4
NCR 4.4
CIE 4.3
Goldstein 4.3
public drinking 4.3
Liddle's syndrome 4.3
PAPA 4.3
HNA 4.2
CEM 4.2
more...
Symptom
iridodonesis 7.3
skin irritant 4.4
rectal pain 4.4
labored breathing 4.2
Halo 4.1
acidity 4.0
Decreased activity 2.9
forgetfulness 2.5
right upper quadrant pain 2.5
CSR 2.5
general problem 2.2
paraparesis 2.1
abnormal gait 1.8
pallor 1.6
incoordination 1.1
leg pain 0.9
blurred vision 0.9
tense 0.8
polydipsia 0.8
sore throat 0.5
lethargy 0.5
HSA 0.4
ophthalmoplegia 0.2
cyanosis 0.1
dysarthria 0.1
hemiplegia -0.0
agitation -0.0
exhaustion -0.2
anorexia -0.2
tremor -0.2
nausea -0.3
collapse -0.3
starvation -0.4
shortness of breath -0.4
ataxia -0.4
hunger -0.5
hemoptysis -0.6
vomiting -0.7
flushing -0.7
spasm -0.9
seizures -1.0
headache -1.3
weakness -1.3
diarrhea -1.3
splenomegaly -1.3
constipation -1.4
fatigue -1.4
insomnia -1.4
thinning -1.5
chest pain -2.1
hypothermia -2.1
dyspnea -2.8
pain -3.3
anesthesia -3.8
Drug
THF 11.9
Pratosartan 9.6
Avapro 9.1
2,4,6-Trinitrophenol 8.9
Padimate O 8.6
7,8-Dihydroneopterin 7.9
InCl3 7.7
CrCl3 7.7
Norvaline 7.5
Leucovorin 7.5
Cobalamin 7.3
2-Methoxyethanol 7.3
Aldomet 7.3
TMC114 6.5
Fenbufen 6.4
TMS 6.4
Allegra 6.3
Allegra 6.3
ZnI2 6.2
BH4 6.2
RPH 6.2
DMAP 6.1
pyridoxal phosphate 5.9
Vitamin B12 5.9
Darunavir 5.7
L-Ser 5.7
TMX 5.6
Hakka 5.6
Alimta 5.6
Compound 19 5.5
Ovulen 5.4
PPA 5.3
ZnCl2 5.3
ZnCl2 5.3
Flavin 5.1
Compound 18 5.1
TPV 5.1
Compound 15 5.0
Compound 9 5.0
Dihydro 4.9
Pyridoxal phosphate 4.8
Lead acetate 4.6
Methyldopa 4.6
FAD 4.6
CEC 4.5
FeCl3 4.5
NaI 4.4
NaI 4.4
NaI 4.4
NaI 4.4
TES 4.4
Trimethoprim-sulfamethoxazole 4.4
CoCl2 4.2
CoCl2 4.2
FLP 4.2
Poloxamer 188 4.2
Estriol 4.1
Alteplase 4.1
Gliclazide 4.1
CSI 4.0
Sodium alginate 4.0
Vitamin B 4.0
Alteplase 4.0
CDX 3.9
Riboflavin 3.9
Pyridoxal 3.9
Alteplase 3.8
Furan 3.8
Silica gel 3.7
Sandostatin 3.7
Sandostatin 3.7
CPO 3.7
Fipronil 3.7
NH3 3.6
EDR 3.6
Ergosterol 3.6
PCP 3.5
Mycophenolic acid 3.5
CDX 3.5
PMEA 3.4
more...
Enzyme
deoxycytidylate methyltransferase 11.9
EC 4.3.1.4 11.3
dimethylglycine oxidase 10.8
10-formyltetrahydrofolate dehydrogenase 10.7
glutamate formiminotransferase 10.5
dimethylglycine dehydrogenase 10.3
dihydrofolate synthetase 9.9
DIPP 9.9
formyltetrahydrofolate synthetase 9.8
T-protein 9.8
serine hydroxymethyltransferase 9.4
NADPH peroxidase 9.3
methanethiol oxidase 9.3
sarcosine dehydrogenase 9.3
glycinamide ribonucleotide transformylase 9.2
ketopantoate hydroxymethyltransferase 9.2
folylpolyglutamate synthetase 9.2
methylenetetrahydrofolate dehydrogenase 9.2
AICAR transformylase 9.1
methionine synthase 8.8
cyclohydrolase 8.8
methionine synthase 8.7
methylenetetrahydrofolate dehydrogenase 8.6
HPPK 8.5
oxalyl-CoA synthetase 8.5
homocysteine methyltransferase 8.5
methionine synthase reductase 8.4
MetE 8.3
dihydroneopterin aldolase 8.3
dCMP hydroxymethylase 8.2
N5,N10-methenyltetrahydromethanopterin cyclohydrolase 8.2
IMP cyclohydrolase 8.2
conjugase 8.1
methionyl-tRNA formyltransferase 8.1
formaldehyde dismutase 8.0
thymidylate synthase 7.8
PurK 7.8
erythritol kinase 7.8
formyl-CoA transferase 7.7
glycine decarboxylase 7.5
dichloromethane dehalogenase 7.5
dihydrofolate reductase 7.4
5,10-methenyltetrahydrofolate synthetase 7.4
alkylglycerol monooxygenase 7.3
sarcosine oxidase 7.3
phospholipid methyltransferase 7.3
threonine aldolase 7.3
glycine dehydrogenase 7.2
glycine dehydrogenase 7.2
PurE 7.2
GAR 7.0
dihydropteroate synthase 6.9
protocatechuate 4,5-dioxygenase 6.7
phosphoethanolamine N-methyltransferase 6.7
glycine dehydrogenase 6.6
staphopain 6.5
cystathionine gamma-synthase 6.4
homoprotocatechuate 2,3-dioxygenase 6.4
aureolysin 6.3
SAICAR synthetase 6.3
cystathionine beta-synthase 6.3
RPH 6.3
11beta-hydroxysteroid dehydrogenase 6.2
betaine-homocysteine methyltransferase 6.2
GTP cyclohydrolase II 6.2
GMP synthase 6.2
CO dehydrogenase 6.1
L-serine dehydratase 6.1
nicotianamine synthase 6.1
porphobilinogenase 6.1
TPP 6.1
phosphopentomutase 6.0
PepX 6.0
urocanase 6.0
phosphoglycerate dehydrogenase 5.9
TPP 5.9
methylmalonyl-CoA mutase 5.9
gentisate 1,2-dioxygenase 5.8
methylenetetrahydrofolate reductase 5.8
5beta-reductase 5.7
more...
Compound
1-naphthylsilane 11.9
C17H14N4 11.9
C26H28O2 11.9
tribromosilane 11.9
2-methyl-2-cyclohexen-1-ol 11.9
1-bromo-4-tert-butylbenzene 11.9
C8H7Br 11.9
7-Methylpterin 11.9
C30H28N4O2 11.9
2,6-dibenzylphenol 11.9
Benzalaniline 11.9
ethyl 2,2-dimethyl-3-oxobutanoate 11.9
C30H28N4O2 11.9
N-methyl-N-phenylacrylamide 11.9
THF 11.9
4-cyclohexene-1,2-diol 11.3
10-formyltetrahydrofolate 11.1
5,10-methylene-THF 11.1
THF 11.1
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C4H8S2 10.9
C9H10N2O4 10.9
C4H8S2 10.9
C26H28O2 10.9
C9H10N2O4 10.9
Scandium trichloride 10.9
Scandium trichloride 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
quinoxalino[2,3-b]quinoxaline 10.9
heptanenitrile 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
tris(2,2,2-trifluoroethyl) phosphite 10.9
C9H10N2O4 10.9
dimethyl 2-aminomalonate 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H14 10.9
4-bromobutyl acetate 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
bis(phenylethynyl)mercury 10.9
C9H10N2O4 10.9
C6H15N3 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
(2-bromovinyl)benzene 10.9
(2-bromovinyl)benzene 10.9
1-chlorododecane 10.9
C9H10N2O4 10.9
Ethyl vinyl sulfide 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H14 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
Dicyclopropyl ketone 10.9
6,7-diphenyldibenzo[e,g][1,4]diazocine 10.9
C9H10N2O4 10.9
C9H14 10.9
5-formiminotetrahydrofolate 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
(2-bromovinyl)benzene 10.9
C9H10N2O4 10.9
C9H10N2O4 10.9
alpha-THF 10.8
more...