Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:EXPT02427 (Atropine)
 3,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of atropine on normal and anomalous A-V pathways were investigated using HBE in 40 cases consisting of 25 subjects without pre-excitation (group I) and 15 cases with WPW syndrome (group II). In group I, A-H interval shortened with a mean decrease of 30% following the administration of atropine (p less than 0.001), while P-A and H-V intervals as well as QRS duration remained unchanged. In group II the electrocardiogram showed WPW syndrome pattern (pattern W) in 12, normalization (pattern N) in 1 and both patterns (pattern WN) in 2 cases during the control study. In 10 cases pattern W persisted after atropine. Atropine changed pattern W to WN in 2 cases, WN to W in 1, WN to N in 1 and N to WN in one case. P-d interval remained constant. Atropine had no effect on the conduction time within atrium. His-Purkinje system and anomalous A-V pathway, but accelerated the transmission through A-V node. Atropine decreased the QRS duration of pattern W in 11 of 13 cases showing pattern W or WN both before and after atropine. Since the QRS duration showing pattern W correlated with P-H interval and (see article) and had the negative correlation with H-d interval (p less than 0.001), fusion mechanism was considered as the genesis of electrocardiographic pattern in most cases with WPW syndrome. Atropine influence was negative on QRS complex of pattern W i2 cases showing the co-existence of Kent bundle and James fibers or exclusive Kent bundle conduction. In the latter case the selection of antiarrhythmic agents should be made with caution. A-V dissociation with junctional rhythm developed in 9 cases (4 in group II) within 2 and a half minutes after atropine. The duration was as short as 15 seconds or less in 6 cases. The continuous tracing is necessary not to miss the AV dissociation. The disappearance of delta wave after atropine was observed during the change to pattern WN and the occurrence of A-V junctional rhythm or beat in 5 of 12 cases showing pattern W prior to the drug administration, and right bundle branch block was disclosed in 2 cases. The normalization of QRS complex also made it possible to measure His-Purkinje conduction time. In this point atropine is superior to the other antiarrhythmic agents which prolong H-V interval. Paroxysmal supraventricular tachycardia induced after atropine revealed shorter A-H with fixed H-V and V-A intervals, compared with the tachycardia before atropine in one case. The administration of atropine serves as an aid to evaluate the participation of anomalous A-V pathway in the tachycardia circuit.
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PMID:The effects of atropine on atrio-ventricular conduction in patients with Wolff-Parkinson-White syndrome. Studies with His bundle electrogram. 101 34

The purpose of this study was to determine the effects of resting vagal tone on accessory atrioventricular (AV) connections. Atropine (0.04 mg/kg) was administered to 13 patients with the Wolff-Parkinson-White syndrome and was found to have the following effects on the accessory AV connection: the anterograde block cycle length shortened from 305 +/- 51 to 279 +/- 54 msec (mean +/- SD; p less than 0.001); the retrograde block cycle length shortened from 288 +/- 57 to 251 +/- 50 msec (p less than 0.001); and the effective refractory period measured at a basic drive cycle length of 400 msec shortened from 295 +/- 45 to 265 +/- 47 msec in the anterograde direction (p less than 0.001) and from 283 +/- 18 to 261 +/- 12 msec in the retrograde direction (p less than 0.01). During atrial fibrillation, the mean ventricular cycle length decreased from 434 +/- 88 to 352 +/- 56 msec (p less than 0.001), and the shortest preexcited RR interval decreased from 302 +/- 56 to 256 +/- 43 msec (p less than 0.01). In another seven patients, propranolol (0.2 mg/kg) was administered before atropine, and atropine lengthened the anterograde block cycle length and the effective refractory period of the accessory AV connection; the magnitude of these effects was similar to that in the patients who did not receive propranolol. In conclusion, these data demonstrate that resting vagal tone exerts a direct depressant effect on accessory AV connections that does not require background sympathetic activity to be manifest.
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PMID:Effects of resting vagal tone on accessory atrioventricular connections. 229 52

The Wolff-Parkinson-White syndrome or its variant, the pre-excitation syndrome, are described in about 1.2 per 1000 of the population, so the anaesthetic management of patients with this syndrome is important. Our experience is reported in 15 elective operations on seven patients with pre-excitation syndrome. The most significant feature is the occurrence of variation of the morphology of QRS complexes. Rhythm disturbance most commonly encountered is supraventricular tachycardia, but different cardiac arrhythmias may occur and sometimes these are fatal. In our study, major complications or cardiac arrhythmias did not occur. With regard to the anaesthetic technique, care should be taken not to produce tachycardia. Atropine is not absolutely contraindicated for premedication. Preoperative use of propranolol or of quinidine is questionable.
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PMID:[Anesthesia in patient with the ventricular pre-excitation syndrome]. 683 Dec 95