Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:EXPT02427 (Atropine)
 3,300 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-six patients with acute myocardial infarction complicated by sinus bradycardia (SB) were treated with intravenous atropine and monitored in a coronary care unit. Atropine decreased or completely abolished premature ventricular contractions (PVCs) and/or bouts of accelerated idioventricular rhythm in 27 of 31 patients (87%) and brought systemic blood pressure up to normal in 15 of 17 patients (88%) with hypotension. In addition, atropine administration was associated with improved atrioventricular conduction in 11 of 13 patients (85%) with acute inferior myocardial infarction associated with 2 degrees or 3 degrees atrioventricular block. Seven patients developed ten significant adverse effects: ventricular tachycardia or fibrillation in three, sustainedsinus tachycardia in three, increased PVCs in three, and toxic psychosis in one. These major adverse effects correlated with either a higher initial dose of atropine (i.e., 1.0 mg aa compared with the usual 0.5 or 0.6 mg) or a total cumulative dose exceeding 2.5 mg over 21/2 hours. Atropine is the drug of choice for management of patients with SB and hypotension and is effective in the treatment of ventricular arrhythmias as well as conduction disturbances in patients with inferior myocardial infarction. Serious adverse effects, however, preclude use of atropine without careful medical supervision.
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PMID:Use of atropine in patients with acute myocardial infarction and sinus bradycardia. 115 75

The mycotoxins cyclopiazonic acid (CPA) and ergotamine, and the neurotransmitter serotonin all have the beta-aminoethylindole moiety in common. These compounds enhanced the peristaltic movements of the jejunum, ileum and estrous uterus and produced broncho-constriction in vitro. Atropine and cyproheptadine were able to counter the CPA-induced peristaltic movements of the ileum and jejunum. L-epinephrine was able to stop the contractions induced by CPA on both estrous and pregnant rat uteri. Unlike chlorpromazine, CPA did not block the inotropic effects of dopamine, epinephrine and serotonin in vas deferens. This indicated that the previously reported toxic effects of CPA (hypothermia, catalepsy, hypokinesia, tremor) which resembled the effects of anti-psychotic drugs (chlorpromazine, reserpine) probably were not due to the blocking of the neurotransmitter-receptors. In contrast to ergotamine, which decreased the inotropic effects of serotonin on the uterus, CPA had no anti-serotonin effects. The uterotonic effect of CPA (similar to that of ergotamine) suggested that CPA also might have an adverse effect on the reproductive function of humans and animals consuming CPA-contaminated foods.
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PMID:Effects of cyclopiazonic acid on the contractility of organs with smooth muscles, and on frog ventricles. 348 54

Two adolescents were admitted to the hospital with acute psychosis and peripheral signs of anticholinergic intoxication. Atropine intoxication due to drinking tea made from thorn apple (Datura stramonium) was diagnosed. After conservative treatment recovery was complete.
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PMID:Anticholinergic intoxication with commercially available thorn apple tea. 793 19

Psychoses caused by an intoxication with atropine or scopolamine are rarely published. Nevertheless atropine and scopolamine were being used in the ancient civilisations and are still in use today. The intoxication is characterised by dose-dependent and substance-dependent syndrome with specific central and peripheral symptoms. Atropine and scopolamine cause a central and peripheral anticholinergic blockade of the muscarine receptor. Psychiatric symptoms include restlessness, excitement, hallucinations, euphoria, disorientation but also stupor, coma and respiratory depression. History, pathophysiology and clinical symptoms of the intoxication due to the alkaloids of the solanaceae are presented. A review of literature is given and four own cases observed in one year are introduced.
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PMID:[Toxic psychoses from atropine and scopolamine]. 969 3