Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: DrugBank:EXPT02397 (
Norvaline
)
22
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Replacement of the C-terminal carboxylic acid functionality of peptide inhibitors of hepatitis C virus (HCV)
NS3
protease (complexed with NS4A peptide cofactor) by activated carbonyl groups does not produce any substantial increase in potency. These latter inhibitors also inhibit a variety of other serine and cysteine proteases whereas the carboxylic acids are specific.
Norvaline
was identified as a chemically stable replacement for the P1 residue of Ac-DDIVPC-OH which was also compatible with activated carbonyl functionalities.
...
PMID:Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. 987 10
