Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: DrugBank:EXPT01586 (
G418
)
2,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To map the
XRCC4
human DNA repair gene subchromosomally, a gamma-ray-resistant human:XR-1 hamster hybrid cell containing fragments of human chromosome 5 and the pSV2neo plasmid was lethally irradiated and fused with the gamma-ray-sensitive XR-1 mutant cell. After selection for
G418
resistance, 2 of a total of 76 hybrids retained wildtype gamma-ray resistance. FISH analysis of normal human lymphocytes using DNA from the two resistant hybrids as probes produced a common region of hybridization at 5q13-q14, suggesting that the
XRCC4
gene is in this region of chromosome 5. The gene was physically localized between D5S427 and D5S401 microsatellite markers and the cytological assignment confirmed using hamster:human hybrids containing known deletions in human chromosome 5.
...
PMID:Regional localization of the XRCC4 human radiation repair gene. 766 75
