Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: DrugBank:EXPT01586 (
G418
)
2,237
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Few therapeutic drugs, other than metronidazole and close derivatives, are currently available to treat
trichomoniasis
. Trichomonas vaginalis is known to have a primitive ribosome based on small subunit ribosomal DNA sequence comparisons. Targeting ribosomal subunits, the aminoglycosides neomycin and geneticin (
G418
, distinct from gentamycin) were tested for activity against T. vaginalis. While neomycin had no effect,
G418
was effective in killing cultured T. vaginalis cells at doses intermediate between those previously effective against prokaryotes and eukaryotes.
G418
cytotoxicity requires further study before recommending this agent as topically applied therapy in refractory patients.
...
PMID:Kinetics of killing or growth of Trichomonas vaginalis in the presence of aminoglycosides, neomycin and geneticin (G418). 1861 65
