Gene/Protein Disease Symptom Drug Enzyme Compound
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 23,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a 4-yr clinical trial, effect on single-photon absorptiometric measurements of arm bones of usual intakes of energy and 14 nutrients plus vitamin-mineral supplements was studied in 99 women, aged 35-65, randomly assigned to placebo (NS) or calcium-supplemented (1.5 g)(S) groups. Cross-sectional analysis of initial bone measurements showed vitamin C (r = 0.313, p less than 0.05) and niacin (r = 0.353, p less than 0.01) correlated with ulna in postmenopausal subjects (n = 67). Longitudinal analysis of bone-change rates of postmenopausal subjects (NS + S) showed higher calcium intakes associated with lower loss rates of humerus bone-mineral content (BMC) (r = 0.360, p less than 0.01). In postmenopausal NS but not S subjects, energy, protein, calcium, phosphorus, zinc, and folate correlate significantly with change in radius BMC; high levels of intake correlated with slower loss (p less than 0.05). Several nutrients besides calcium are related to bone loss in women.
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PMID:Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: longitudinal and cross-sectional analysis. 349 33

This study was carried out to develop an in vitro system for the analysis of bone modeling (coincidentally occurring bone growth, formation, mineralization, and resorption) as is seen during bone development. The fetuses of pregnant mice previously labeled with 45Ca were removed on Days 15, 16, and 17 of gestation. The radii and ulnae were dissected free and cultured for up to 6 days in a chemically defined medium (BGJ) supplemented with fetal calf serum or human serum albumin and 150 micrograms/ml vitamin C. The change in bone length over the culture period was measured as were the changes in calcium and phosphorus content, the hydroxyproline: protein ratio, and the percent 45Ca released into the medium. The effect of insulin and parathyroid extract on the system was also examined. The results indicate that cultures of 16-day-old fetal bones provided the most suitable model. During culture there was a continuous increase in bone length as well as calcium and phosphorus content in the ratio of 2:1, a significant increase in the hydroxyproline content, and a continuous release of 45Ca into the medium. Parathyroid extract caused a dose-dependent inhibition of both growth in diaphyseal length and calcium and phosphorus uptake with an increase in 45Ca release into the medium. Insulin at 10(-9) M and 10(-10) M resulted in a significant increase in diaphyseal length and calcium and phosphorus uptake without affecting 45Ca release. These results indicate that the assay described is suitable for the study of bone modeling, providing a means to measure bone growth, formation, calcification, and resorption. The direct effect of various factors on bone modeling can also be measured.
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PMID:The development of fetal mice long bones in vitro: an assay of bone modeling. 351 84

Protein-calorie malnutrition is prevalent among individuals with chronic obstructive pulmonary disease (COPD), and suboptimal body weight has been associated with increased morbidity and mortality. Pulmonary function, anthropometric measurements, and dietary intake were evaluated in 64 outpatients with stable COPD to assess interrelationships of those parameters. Those individuals with body weights less than 75% of standard for height, age, and sex had the greatest degree of airway obstruction, poorest lung diffusing capacity, and greatest loss of body fat and muscle mass. Contrary to what had been anticipated, calorie and protein intake levels were highest in the less than 75% of standard body weight group, decreased as relative body weight increased, and were lowest in the greater than 105% of standard body weight group. Those results indicate that caloric needs increase as COPD progresses. Intake levels of calcium, phosphorus, iron, vitamin A, thiamin, riboflavin, niacin, and vitamin C were adequate in terms of the RDAs and were not related to relative body weight.
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PMID:Dietary evaluation of outpatients with chronic obstructive pulmonary disease. 372 55

This study was designed to measure and evaluate the dietary intake and symptoms of anorexia nervosa in female university dancers (no. = 21) and a control group of female university non-dancers (no. = 29). Three-day food records were analyzed for calories, protein, vitamin A, vitamin C, thiamin, riboflavin, niacin, calcium, phosphorus, and iron. Symptoms of anorexia nervosa were determined through the use of an objective questionnaire, the Eating Attitudes Test (EAT). The percent of subjects who consumed less than two-thirds of the Recommended Dietary Allowance (RDA) for energy was significantly higher in the dance group (28.6% vs. 10.3%, p less than .005). Seventy percent of the total study population consumed less than two-thirds of the RDA for at least one nutrient, and 24% consumed less than two-thirds of the RDA for three or more nutrients. Thirty-three percent of the dancers and 13.8% of the controls scored in the range symptomatic of anorexia nervosa on the EAT, a difference that was statistically significant (p less than .005). The results indicate that both female university dancers and female university students may be at risk for nutrient deficiency and anorexia nervosa.
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PMID:Dietary intake and symptoms of anorexia nervosa in female university dancers. 379 36

Associations between blood pressure and intakes of 61 dietary variables assessed by 24-h recall method were investigated in 615 men of Japanese ancestry living in Hawaii who had no history of cardiovascular disease or treated hypertension. Magnesium, calcium, phosphorus, potassium, fiber, vegetable protein, starch, vitamin C, and vitamin D intakes were significant variables that showed inverse associations with blood pressure in univariate and a multivariate analyses. Magnesium had the strongest association with blood pressure, which supports recent interest in its relation to blood pressure. Nevertheless, it was not possible to separate the effect of magnesium from that of other variables because of the problem of high intercorrelation among many nutrients. While recommendations based upon cross-sectional studies must be viewed cautiously, these results suggest that foods such as vegetables, fruits, whole grains, and low-fat dairy items are major sources of nutrients that may be protective against hypertension.
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PMID:Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study. 381 46

The second National Health and Nutrition Examination Survey, 1976 to 1980, incorporated medical history, physical examination, anthropometric measurements, dietary information (24-hour recall and food frequency), laboratory tests, and radiographs. In linear regressions of adjusted data from 2,695 children aged 7 years and younger, 91% of the variance in height, 72% of the variance in weight, and 58% of the variance in chest circumference were explained by six variables: age, race, sex, blood lead level, total calories or protein, and hematocrit or transferrin saturation level. Variables that did not significantly improve the models predicting growth included family income, degree of urbanization, serum albumin, copper, iron, and zinc levels, dietary carbohydrate, fat, calcium, potassium, phosphorus, vitamin A, vitamin C, niacin, riboflavin, and thiamine. The highly significant correlation of blood lead level with growth does not contradict the established association of childhood deprivation with increased lead exposure and with nutritional deficiences known to enhance lead absorption. Blood lead level may also represent a composite marker for unidentified genetic, ethnic, environmental, and sociocultural variables, other than race, sex, and nutrition, that affect growth. However, the correlation of stature, particularly height, with blood lead levels in the range of 5 to 35 micrograms/dL is so statistically significant that it merits investigation in other surveys and consideration of the multiple biologic mechanisms by which low-level lead exposure could impair the growth of children.
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PMID:Relationship between childhood blood lead levels and stature. 395 9

With the use of data from the Spring 1977 sample of the USDA Nationwide Food Consumption Survey 1977-78, 1- and 3-day nutrient intakes for 8,779 individuals in 22 sex-age groups in the 48 conterminous states were compared. For most nutrients studied, 3-day mean intakes and day 1 mean intakes showed little difference. Mean intakes for day 1 and for days 2 and 3 combined were not significantly different for most sex-age groups for most nutrients. The few statistically significant differences observed for energy, fat, and carbohydrate could have been the result of chance and therefore have little practical significance. Regression analysis indicated that day 1 intake was strongest as a predictor of intake on subsequent days for energy, carbohydrate, calcium, magnesium, and phosphorus; less strong for protein, fat, iron, thiamin, riboflavin, niacin, vitamin B-6, and vitamin C; and poorest for vitamin A.
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PMID:One-day and 3-day nutrient intakes by individuals--Nationwide Food Consumption Survey findings, Spring 1977. 397 20

Dietary data from 11,658 adult respondents in the second National Health and Nutrition Examination Survey were used to provide quantitative information regarding the contribution of specific foods to the total population intake of the following 10 nutrients: vitamin A, thiamine, riboflavin, niacin, vitamin C, iron, phosphorus, calcium, sodium, and potassium. Data are reported in the companion paper regarding the number of adults in the US population consuming each of 147 food items, representing all foods reported by these respondents. The percentage of total nutrient intake which each food provides is presented for the top 50 contributors of each of the nutrients listed above. Foods sometimes overlooked as important sources are found in some instances to be quantitatively important to population intake, such as spaghetti dishes as an independent source of carotenoids. These data should be useful to epidemiologists with a substantive interest in dietary etiologies or a methodological interest in the development of dietary assessment instruments. In addition, they may be useful to health care planners or nutrition educators.
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PMID:Nutrient sources in the American diet: quantitative data from the NHANES II survey. I. Vitamins and minerals. 401 90

Dietary intakes of essential nutrients were measured as part of a population-based investigation of diabetes and cardiovascular risk factors in Mexican-Americans and Anglo-Americans in San Antonio, Texas. Twenty-four hour dietary recalls were conducted on 2134 individuals residing in three socioeconomically distinct neighborhoods: low-income, middle-income, and upper-income. Mean intakes of calcium, vitamin A and vitamin C were significantly lower among Mexican-Americans than among Anglos. Intake of vitamin C was most affected by socioeconomic status. Females of both ethnic groups consumed less than their RDA for calcium and iron. Intakes of B vitamins, phosphorus, and potassium were adequate, with few ethnic or socioeconomic differences.
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PMID:Dietary intakes of essential nutrients among Mexican-Americans and Anglo-Americans: the San Antonio Heart Study. 402

Forty-two female college students, age 18-29 yr. and consuming nutritionally balanced meals in the college cafeteria participated. Subjects discontinued all vitamin-mineral supplements (VMS) for 17 days and were randomly assigned to one of two treatments, either a placebo, or VMS supplying the United States Recommended Daily Allowance (USRDA) of all vitamins, zinc, iron, iodine, copper, and 60% of the USRDA of calcium, 50% of magnesium and 45% of phosphorus. Treatments were consumed for 77 days. Fasting pre-and post-treatment blood chemistries were compared. VMS yielded significant increases (p less than 0.05) in serum vitamin B-12 (+25.05 pg/ml), vitamin C (+0.35 mg/dl) and folate (+7.40 ng/ml). No significant changes (p greater than 0.05) in hematological or other blood chemistries were observed. Significant decreases in the number of below-normal serum indicators of vitamin status (p less than 0.05) and iron status (p less than 0.005) were seen with VMS. No significant changes were seen with placebo (p greater than 0.05).
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PMID:Multivitamin-mineral supplementation: effects on blood chemistries of college-age women. 409 Nov 51


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