Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: DrugBank:BIOD00060 (IL-1ra)
 1,370 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
IL-1ra 823
cytokine 463
IL-6 400
IL-1 381
IL-10 270
IL-8 226
TNF 214
IL-1 beta 199
IL-1RA 178
IRAP 149
tumor necrosis factor 112
TNF-alpha 111
IL-4 103
Sep 87
IL-2 86
Cytokine 82
interleukin-1 receptor antagonist 81
lipopolysaccharide 78
Mol 76
insulin 75
more...
Disease
rheumatoid arthritis 85
cancer 76
arthritis 63
tumor 40
MIP 39
sepsis 35
sepsis 35
gastric cancer 32
diabetes 28
periodontitis 20
stroke 19
obesity 19
rash 18
asthma 18
depression 17
Alzheimer's disease 17
osteoarthritis 17
familial Mediterranean fever 17
Still's disease 15
type 2 diabetes 15
more...
Symptom
pain 41
arthralgia 10
fatigue 9
respiratory distress 8
exhaustion 8
seizures 7
analgesia 7
overweight 5
anorexia 5
diarrhea 5
myalgia 4
dyspnea 4
Neuropathic pain 4
anesthesia 3
abdominal pain 3
functional recovery 3
cachexia 3
bone pain 3
wheezing 3
swollen joints 3
more...
Drug
IL-1ra 1370
Anakinra 252
IL-2 86
CSF 50
G-CSF 47
IFN-gamma 32
Adalimumab 21
Infliximab 14
Infliximab 14
Tocilizumab 13
Dermatol 11
Abatacept 10
Bevacizumab 10
Bortezomib 10
Pemetrexed disodium 9
Pregabalin 9
p75 9
Everolimus 9
Sunitinib malate 8
Sorafenib 8
more...
Enzyme
MIP 39
mitogen-activated protein kinase 29
caspase-1 19
oxytocinase 15
peroxidase 15
ERK 12
collagenase 10
focal adhesion kinase 8
lactate dehydrogenase 8
protein kinase C 7
renin 7
reverse transcriptase 6
NO synthase 6
creatine kinase 6
phosphatidylinositol 3-kinase 5
alkaline phosphatase 5
glutathione S-transferase 4
thrombin 4
CD13 4
arginase 3
more...
Compound
TNF 214
Dec 97
Clin 95
DNA 60
glucose 52
oxygen 31
acetate 21
Insulin 21
sodium 19
water 19
calcium 17
THP 15
nitric oxide 15
THP 15
tyrosine 14
Etanercept 11
phosphate 10
arginine 10
PEG 9
PMA 9
more...