Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: DrugBank:APRD00691 (EE2)
7,802 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
estrogen receptor 717
Sep 535
Mol 369
aromatase 247
FSH 243
insulin 199
prolactin 193
progesterone receptor 140
Gen 120
LHRH 118
follicle-stimulating hormone 113
estrogen receptor alpha 88
collagen 80
Aromatase 73
sex hormone-binding globulin 71
cytochrome P450 70
RIN 68
growth hormone 65
chorionic gonadotropin 61
microsomal 61
androgen receptor 59
oxytocin 59
PRL 55
ER beta 55
epidermal growth factor 55
cytokine 54
kit 53
albumin 52
CA1 50
sex hormone binding globulin 49
Prolactin 47
P450 46
alkaline phosphatase 46
ER-alpha 43
caspase-3 43
hemoglobin 42
peroxidase 41
leptin 41
insulin-like growth factor-I 40
HDL 40
more...
Disease
breast cancer 369
cancer 309
tumor 268
uterus 260
MCF 186
hepatitis C 172
Steroids 108
carcinoma 73
depression 73
hypertension 71
osteoporosis 70
amenorrhea 70
carcinogenesis 65
acne 63
hepatitis 59
infertility 58
obesity 55
hepatitis B 51
ischemia 50
endometrial cancer 49
diabetes 48
SEM 46
EIA 45
cardiovascular disease 45
atherosclerosis 42
abortion 38
HIV 38
tumor growth 37
hepatocellular carcinoma 36
endometriosis 34
vagina 34
stroke 34
polycystic ovary syndrome 33
aggression 31
Alzheimer's disease 30
Pituitary 29
chronic hepatitis 28
prostate cancer 28
metastases 27
cold 26
more...
Symptom
headache 71
nausea 69
pain 66
masculinization 25
vomiting 22
fatigue 22
anesthesia 21
Ill 20
discomfort 17
seizures 17
irregular bleeding 16
abdominal pain 16
nausea and vomiting 15
discomfort 14
mastalgia 14
pelvic pain 14
analgesia 13
hot flashes 12
dizziness 10
hot flushes 10
collapse 9
anorexia 8
diarrhea 8
menopausal symptoms 8
dyspnea 7
skin irritation 7
weakness 7
overweight 6
agitation 6
thinning 6
bloating 6
functional recovery 5
starvation 5
hepatomegaly 5
erythema 5
hunger 4
flushing 4
memory loss 4
back pain 4
acute stress 4
more...
Drug
EE2 7802
ENT 1548
MAP 340
Norplant 318
ICI 165
Estrogens 112
Levonorgestrel 107
Encore 107
Ovulen 40
Estriol 30
Depo-Provera 25
Ortho Tri-Cyclen 23
Dermatol 23
DMAP 22
Monit 22
caffeine 21
Luteinizing 19
Mircette 18
Dihydrotestosterone 18
Spectrum 17
Bayer 16
Spectrum 16
Nephron 15
Norplant 14
DHT 14
DHT 14
Premarin 14
HCG 14
ascorbate 13
NADH 12
Cardiovasc 12
Gel 10
Indomethacin 10
PTH 9
TiO2 9
CTX 9
Evra 9
Retinoic acid 8
Leaf 8
lysine 8
more...
Enzyme
mitogen-activated protein kinase 94
ERK 75
protein kinase 70
peroxidase 57
luciferase 48
alanine aminotransferase 48
alkaline phosphatase 46
protein kinase C 40
superoxide dismutase 31
catalase 31
caspase-3 31
thromboplastin 27
HSD 26
RNase 25
RNase 25
focal adhesion kinase 24
adenylate cyclase 24
renin 22
ATPase 21
acetylcholinesterase 20
sulfatase 20
NO synthase 19
glutathione peroxidase 19
collagenase 18
tyrosine hydroxylase 18
phospholipase C 17
reverse transcriptase 16
ribonuclease 16
ribonuclease 16
aspartate aminotransferase 15
lactate dehydrogenase 14
laccase 14
glutathione S-transferase 13
UDP-glucuronosyltransferase 13
MEK 12
phosphodiesterase 12
MPP 12
phosphatidylinositol 3-kinase 11
AMP-activated protein kinase 11
glucose-6-phosphate dehydrogenase 10
more...
Compound
Estradiol 4541
Estrogen 706
water 701
Dec 573
Clin 482
Progesterone 319
DNA 316
Estrogen 261
acetate 210
calcium 184
Testosterone 176
Testosterone 174
ICI 165
sulfate 157
glucose 154
sodium 116
oxygen 111
Abbott 97
cAMP 79
phosphate 74
Premarin 73
hydrogen 69
NEE 68
Tamoxifen 67
Tamoxifen 67
nitrogen 63
Estrone 59
phenol 56
glutamate 56
nitric oxide 55
ethanol 53
salt 48
MAP 44
MDA 44
tyrosine 44
NAD 43
potassium 42
ATP 40
iron 40
copper 39
more...