Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: DrugBank:APRD00691 (
EE2
)
7,802
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
estrogen receptor
717
Sep
535
Mol
369
aromatase
247
FSH
243
insulin
199
prolactin
193
progesterone receptor
140
Gen
120
LHRH
118
follicle-stimulating hormone
113
estrogen receptor alpha
88
collagen
80
Aromatase
73
sex hormone-binding globulin
71
cytochrome P450
70
RIN
68
growth hormone
65
chorionic gonadotropin
61
microsomal
61
androgen receptor
59
oxytocin
59
PRL
55
ER beta
55
epidermal growth factor
55
cytokine
54
kit
53
albumin
52
CA1
50
sex hormone binding globulin
49
Prolactin
47
P450
46
alkaline phosphatase
46
ER-alpha
43
caspase-3
43
hemoglobin
42
peroxidase
41
leptin
41
insulin-like growth factor-I
40
HDL
40
more...
Disease
breast cancer
369
cancer
309
tumor
268
uterus
260
MCF
186
hepatitis C
172
Steroids
108
carcinoma
73
depression
73
hypertension
71
osteoporosis
70
amenorrhea
70
carcinogenesis
65
acne
63
hepatitis
59
infertility
58
obesity
55
hepatitis B
51
ischemia
50
endometrial cancer
49
diabetes
48
SEM
46
EIA
45
cardiovascular disease
45
atherosclerosis
42
abortion
38
HIV
38
tumor growth
37
hepatocellular carcinoma
36
endometriosis
34
vagina
34
stroke
34
polycystic ovary syndrome
33
aggression
31
Alzheimer's disease
30
Pituitary
29
chronic hepatitis
28
prostate cancer
28
metastases
27
cold
26
more...
Symptom
headache
71
nausea
69
pain
66
masculinization
25
vomiting
22
fatigue
22
anesthesia
21
Ill
20
discomfort
17
seizures
17
irregular bleeding
16
abdominal pain
16
nausea and vomiting
15
discomfort
14
mastalgia
14
pelvic pain
14
analgesia
13
hot flashes
12
dizziness
10
hot flushes
10
collapse
9
anorexia
8
diarrhea
8
menopausal symptoms
8
dyspnea
7
skin irritation
7
weakness
7
overweight
6
agitation
6
thinning
6
bloating
6
functional recovery
5
starvation
5
hepatomegaly
5
erythema
5
hunger
4
flushing
4
memory loss
4
back pain
4
acute stress
4
more...
Drug
EE2
7802
ENT
1548
MAP
340
Norplant
318
ICI
165
Estrogens
112
Levonorgestrel
107
Encore
107
Ovulen
40
Estriol
30
Depo-Provera
25
Ortho Tri-Cyclen
23
Dermatol
23
DMAP
22
Monit
22
caffeine
21
Luteinizing
19
Mircette
18
Dihydrotestosterone
18
Spectrum
17
Bayer
16
Spectrum
16
Nephron
15
Norplant
14
DHT
14
DHT
14
Premarin
14
HCG
14
ascorbate
13
NADH
12
Cardiovasc
12
Gel
10
Indomethacin
10
PTH
9
TiO2
9
CTX
9
Evra
9
Retinoic acid
8
Leaf
8
lysine
8
more...
Enzyme
mitogen-activated protein kinase
94
ERK
75
protein kinase
70
peroxidase
57
luciferase
48
alanine aminotransferase
48
alkaline phosphatase
46
protein kinase C
40
superoxide dismutase
31
catalase
31
caspase-3
31
thromboplastin
27
HSD
26
RNase
25
RNase
25
focal adhesion kinase
24
adenylate cyclase
24
renin
22
ATPase
21
acetylcholinesterase
20
sulfatase
20
NO synthase
19
glutathione peroxidase
19
collagenase
18
tyrosine hydroxylase
18
phospholipase C
17
reverse transcriptase
16
ribonuclease
16
ribonuclease
16
aspartate aminotransferase
15
lactate dehydrogenase
14
laccase
14
glutathione S-transferase
13
UDP-glucuronosyltransferase
13
MEK
12
phosphodiesterase
12
MPP
12
phosphatidylinositol 3-kinase
11
AMP-activated protein kinase
11
glucose-6-phosphate dehydrogenase
10
more...
Compound
Estradiol
4541
Estrogen
706
water
701
Dec
573
Clin
482
Progesterone
319
DNA
316
Estrogen
261
acetate
210
calcium
184
Testosterone
176
Testosterone
174
ICI
165
sulfate
157
glucose
154
sodium
116
oxygen
111
Abbott
97
cAMP
79
phosphate
74
Premarin
73
hydrogen
69
NEE
68
Tamoxifen
67
Tamoxifen
67
nitrogen
63
Estrone
59
phenol
56
glutamate
56
nitric oxide
55
ethanol
53
salt
48
MAP
44
MDA
44
tyrosine
44
NAD
43
potassium
42
ATP
40
iron
40
copper
39
more...