Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:APRD00691 (EE2)
 7,802 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of a series of steroid hormones on the pentetrazol convulsing action, hexobarbital narcotic action and hepatic drug metabolizing enzyme activities was determined in rats. All steroid compounds used antagonized the pentetrazol effect: the most potent was cortisone and the least potent testosterone. Glucocorticoids and androgens shortened the hexobarbital sleeping time and increased the hepatic drug metabolizing enzyme activity. Estradiol exhibited the opposite effect, whereas progesterone and desoxycorticosterone did not affect these two parameters.
Pharmazie 1975 Sep
PMID:A comparative study of the effect of some steroid hormones on the response of rats to other drugs. 12 82

A competitive protein binding radioassay system using a rabbit uterine cytosol preparation for the measurement of ethynylestradiol [EE2e] in human plasma has been developed. Sephadex LH-20 column chromatography is used for the separation of the estrogens prior to assay. EE2 levels were measured in 23 normotensive subjects on contraceptive pills containing either 50 mug of EE2 or mestranol. The EE2 values ranged from 144 to 248 pg with a mean of 211 pg (S.D. +/- 37.94). The method is sensitive enough to detect 25 pg of EE2 in plasma. The intra- and inter-assay coefficients of variation were 7.54% and 10.75%, respectively. Water blanks and plasma blanks from subjects not on pills gave negligible readings for EE2.
Clin Chim Acta 1975 Sep 16
PMID:A competitive protein binding radioassay for 17alpha-ethynylestradiol in human plasma. 17 26

The acute and chronic effects of estradiol (E2) on the serum levels of four delta5,3-beta hydroxysteroids and their four delta4, 3-keto products were studied in four ovariectomized women with and without adrenal stimulation by ACTH. Six hour infusions of saline and of synthetic 1-24 ACTH were administered and later repeated with a two hour infusion of E2 50 mug/h. The patients were then given 50 mug of ethinyl estradiol (EE2) p.o. for 4 to 6 weeks and the control and ACTH infusions were again repeated. Levels of pregnenolone3 (Pe), 17alpha-hydroxypregnenolone (17 Pe), progesterone (Po), 17alpha-hydroxyprogesterone (17 Po), dehydroepiandrosterone (DHEA), androstenedione (Adione), androstenediol (Adiol), and testosterone (T), as well as cortisol and DHEA-sulfate were measured by radioimmunoassay on serum samples taken at 1200 and 1300 h. There was no significant effect of E2 or EE2 in the doses administered with or without exogenous ACTH on 3 betaOHSD activity as reflected in absolute steroid levels or in the ratio of concentrations of each delta5:delta4 steroid pair. During the 4th and 5th hour of ACTH infusion, the plasma level of 17 Pe (mean 22.5-fold stimulation) was most elevated, followed by 17 Po (12.5-fold), Pe (10-fold), cortisol (5.9-fold) and Po (4.5-fold), with smaller increases for the other steroids. These results, as well as the pattern of change in plasma levels in one of the subjects in whom fifteen minute samples were measured, provide further evidence suggesting that the major pathway for cortisol biosynthesis in vivo proceeds from Pe via 17 Pe, and not via Po.
J Clin Endocrinol Metab 1976 Sep
PMID:Effects of estrogens on adrenal 3 beta-hydroxysteroid dehydrogenase in ovariectomized women. 18 11

The effects of oral contraceptive treatment on the pituitary-adrenal axis were studied. Secretion rate and plasma concentration of the adrenocortical steroid cortisol was modified in subjects treated with estrogenic and/or progestational steroids. Concentrations of adrenocorticotropin (ACTH) and cortisol in plasma obtained at 0800-0900 hours from a group of women with normal cyclic menses (n=4) ranged from 78-120 pg/ml and 77-137 pg/ml, respectively. Although significant cyclic changes in plasma levels of luteinizing hormone (LH) follicle stimulating hormone (FSH), estradiol, and progesterone occurred during the ovarian cycle, no obvious cyclic fluctuations in plasma levels of ACTH or cortisol were observed. Plasma concentrations of women treated with Norinyl 1 + 80 (1 mg of norethindrone and .08 mg of mestranol) of LH, FSH, estradiol, and progesterone were significantly lower (P .001) than plasma levels of these hormones in normal women during the ovarian cycle. Mean daily plasma concentrations of ACTH were significantly lower ( P .001), whereas plasma cortisol levels were significantly higher (P .001) in women treated with oral contraceptives compared to the levels of these hormones in untreated ovulatory women.
J Clin Endocrinol Metab 1979 Sep
PMID:Plasma levels of adrenocorticotropin and cortisol in women receiving oral contraceptive steroid treatment. 22 73

Estradiol is shown to induce histidine decarboxylase and histamine to activate adenylate cyclase in the rat uterus. Cyclic AMP like histamine simulates the effect of estradiol, intensifying RNA synthesis and inducing glycolytic enzymes and uterus inhibition. It was found by autoradiography that 3H-estradiol is accepted by the nuclei of some myometrium cells, 3H-histamine by their cytoplasm and 3H-cAMP is selectively bound by endothelium cells of the uterus capillaries. The estradiol messengers (histamine and cAMP) seem to mediate hormonal effect of some uterus heterofunctional cells forming a kind of multicellular functional system.
Biull Eksp Biol Med 1979 Sep
PMID:[Multiphasic regulatory system mediating the effect of estradiol in rat uterus]. 22 31

The content and uridine incorporation into nuclear RNA of anterior pituitary gland was studied in vitro in intact, castrated and neonatally testosterone treated rats of both sexes. In female rats a higher RNA content and a lower uridine incorporation rate could be observed than in males. The castration resulted in a marked increase of RNA content and uridine incorporation in male rats. Ovariectomy was followed by a decrease of RNA content which was accompanied by an increase of incorporation rate. Estradiol administration produced a biphasic change of RNA content and uridine incorporation in ovariectomized rats. From these findings a repressive action of estrogens on the nuclear RNA synthesis may be suggested. Neonatal testosterone treatment resulted in alterations of RNA synthesis which could be observed in both sexes.
Endocrinol Exp 1977 Sep
PMID:Nuclear RNA content and synthesis in anterior pituitary in intact, castrated and androgen sterilized rats. 30 86

Binding activity characteristics in human endometrium of estradiol-17-beta (E2), estrone (E1), estriol (E3), and 17-alpha-ethinylestradiol-17-beta (EE2) were determined in cytosol extracts. Unequal binding was observed. A lower affinity of E3 binding in endometrial cytosol when compared to E2 was parallel to a slower rate of association and to a higher rate of dissociation. For EE2, the slightly higher affinity was parallel to a higher rate of association and a slower dissociation rate. For E1, the association rate constant was 1/2 of that for E2 when the total number of binding sites able to bind E2 was considered in the calculation. Association rate constant was only 23% of that for E2 when the total number of binding sites able to bind E1 was considered in the calculation, and the dissociation rate was neglected. The dissociation rate of E1 receptor complexes was 20 times higher at both 0 and 25 degrees centigrade than the E2 receptor complexes. An unequal number of binding sites was measured for E2 and E1, an unexpected finding. Also observed was an unequal binding for E2 and E1 which varied during the menstrual cycle, and it is suggested that progesterone may be the regulatory factor since E1 and E2 receptors increased during the luteal phase.
J Steroid Biochem 1979 Sep
PMID:Unequal binding of estrogens in human endometrium. 51 46

Changes in nesting frequency, serum LH, progesterone, and estradiol were measured in relation to the onset of broodiness in turkeys. In each of two experiments the frequency of nest visits increased about four-fold in the 5 to 7 day interval before oviposition of the last egg associated with the onset of broodiness. In the 9 day period prior to oviposition of this egg LH levels declined from about 12 ng/ml to 6 to 7 ng/ml (Experiment 1) and from about 9 ng/ml to less than 5 ng/ml (Experiment 2). Progesterone levels declined during this same period going from about 2 to 2.5 ng/ml down to less than .5 ng/ml. In the 5 day period following the nadir in serum LH, which occurred on or a day or two after the last egg, levels of this hormone again rose substantially. Estradiol levels, assayed in Experiment 2, were generally low with many samples below detectability (less than 3 pg/ml). There were no consistent changes in serum estradiol until the day before oviposition of the last egg. On this day, and on the subsequent four days, mean estradiol levels were at a nadir (6 to 9 pg/ml) and rose to levels averaging over 11 pg/ml in the following five day period.
Poult Sci 1979 Sep
PMID:Serum luteinizing hormone, progesterone, and estradiol levels in relation to broodiness in the turkey (Meleagris gallapavo). 52 93

Estrogenic hormones first stimulate and then inhibit DNA synthesis in the uterus of the immature rat. Both the stimulatory and the inhibitory effects depend on the sustained presence of estrogen. Thus, estriol, which is equal in effectiveness to estradiol on early (up to 6 hr) responses, has only a partial stimulatory effect on DNA synthesis. Estradiol initially stimulates DNA synthesis, but the sustained presence of this steroid inhibits further synthesis of this macromolecule and cell division. These observations are discussed in terms of their relationship to current models of estrogen action and to estrogen dependency in some types of cancer.
J Toxicol Environ Health 1977 Sep
PMID:Hormone regulation of growth: stimulatory and inhibitory influences of estrogens on DNA synthesis. 56 46

Two experiments assessing the modification of visual acuity by fading plus feedback procedures are presented. The training procedure involved a gradual increase of the distance myopic subjects could accurately discriminate letters requiring a minimum of 20/20 vision at approximately 23 feet. In Experiment I experimental and matched control groups of mildly to moderately myopic subjects were compared on repeated Ortho-rater examinations of visual acuity. The experimental group showed a significant improvement relative to the control group who received no training. Multiple-baseline across-stimuli designs were used in Experiment II to evaluate training effects for another group of subjects with moderate to severe myopia. Two measures of acuity were obtained. Accuracy of discrimination of letters at various preselected distances was determined each session while Ortho-rater examinations were given periodically throughout training. Changes in discrimination accuracy over sessions appeared to be related to fading for three of the four subjects, and Ortho-rater acuity changes were observed for each subject. Some short-term maintenance of improved vision was evident on both acuity measures.
J Behav Med 1978 Sep
PMID:Fading and feedback in the modification of visual acuity. 75 62


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