Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: DrugBank:APRD00345 (ICI)
5,388 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein estrogen receptor 1314 beta 1 566 Mol 492 Sep 361 opioid receptor 215 progesterone receptor 150 estrogen receptor alpha 146 AMP 120 ER beta 119 oestrogen receptor 117 adenylate cyclase 117 BRL 108 aromatase 102 insulin 97 ERK1 91 nitric oxide synthase 91 pS2 88 MAPK 79 Leu5 77 cytokine 76 adenylyl cyclase 75 ERK 72 cyclooxygenase 69 androgen receptor 69 phosphodiesterase 68 ER-alpha 68 ATP 60 beta-endorphin 60 cyclin D1 60 Estrogen receptor 58 dynorphin 57 prolactin 57 5-hydroxytryptamine 56 alkaline phosphatase 55 PPT 54 caspase-3 54 5-HT1A 52 p38 52 lipopolysaccharide 49 GPR30 45 more...

Disease breast cancer 608 MCF 466 cancer 382 tumor 213 uterus 161 asthma 96 carcinoma 86 pertussis 73 hypertension 70 prostate cancer 66 depression 61 osteoporosis 60 carcinogenesis 55 heart failure 51 Steroids 48 tumor growth 48 malaria 47 sympathomimetic 45 NAME 45 ischemia 43 neuroblastoma 36 diabetes 36 endometrial cancer 33 stroke 31 SCH 31 cardiovascular disease 29 cold 27 ovarian cancer 25 tumorigenesis 24 Alzheimer's disease 23 adenocarcinoma 23 metastases 23 hepatocellular carcinoma 23 SEM 22 myocardial infarction 20 myocardial ischemia 20 Evans 20 atherosclerosis 20 cholera 19 endometrial adenocarcinoma 19 more...

Symptom pain 70 analgesia 35 anesthesia 30 tremor 22 seizures 18 hypothermia 17 menopausal symptoms 8 hot flushes 8 angina 8 acute stress 7 bone pain 7 dyspnea 7 diarrhea 7 exhaustion 6 cough 6 hot flashes 5 fatigue 4 discomfort 4 discomfort 4 masculinization 3 hypercapnia 3 vomiting 3 anorexia 3 spasm 3 nausea and vomiting 3 functional recovery 3 Welt 3 insomnia 3 collapse 2 polyuria 2 dysuria 2 acute pain 2 Involuntary Movement 2 overweight 2 Excitability 2 Neuropathic pain 2 flushing 2 sleepiness 2 splenomegaly 2 ataxia 2 more...

Drug ICI 5388 EE2 165 Cardiovasc 81 Fulvestrant 74 Estrogens 74 Atenolol 54 Zoladex 46 Zoladex 46 MAP 44 Nephron 43 Raloxifene 32 Salbutamol 31 Dermatol 17 ROS 16 Forskolin 16 caffeine 16 Casodex 13 Clonidine 12 Fenoterol 12 lysine 11 Peridex 11 Fansidar 10 Fansidar 10 Seroquel 10 CTX 10 Phentolamine 10 Indomethacin 8 Rolipram 8 IL-2 8 Dopexamine 7 Gel 7 2-Methoxyestradiol 7 R1881 7 Inderal 6 DHT 6 4-Hydroxytamoxifen 6 NADH 6 Vivalan 6 IFN-gamma 6 Angiotensin II 6 more...

Enzyme mitogen-activated protein kinase 251 protein kinase 168 luciferase 145 ERK 122 adenylate cyclase 118 protein kinase C 80 phosphodiesterase 68 NO synthase 58 MEK 57 alkaline phosphatase 55 caspase-3 41 phosphatidylinositol 3-kinase 36 catalase 35 aldose reductase 35 phospholipase C 34 peroxidase 33 renin 31 cathepsin D 28 MPP 27 ATPase 26 neutrophil elastase 25 focal adhesion kinase 25 reverse transcriptase 24 thymidylate synthase 23 lipoxygenase 21 guanylate cyclase 20 lactate dehydrogenase 20 chloramphenicol acetyltransferase 20 cdc2 20 elastase 19 NOS 18 phospholipase A2 16 superoxide dismutase 16 proteasome 15 beta-galactosidase 14 PDE 14 NADPH oxidase 13 creatine kinase 13 NADPH oxidase 12 thrombin 12 more...

Compound ICI 5338 Dec 413 noradrenaline 265 DNA 263 Estradiol 255 calcium 243 cAMP 241 Estrogen 221 Estrogen 215 Clin 192 tyrosine 154 Isoproterenol 148 Tamoxifen 139 Tamoxifen 134 nitric oxide 132 MDA 128 sodium 128 AMP 125 Phe 122 glucose 115 BRL 108 arginine 103 leucine 98 oxygen 93 Propranolol 93 water 93 5-HT 91 Gly 91 Propranolol 88 acetate 82 potassium 80 threonine 65 glutamate 61 ATP 60 NAD 55 Naloxone 49 Pyrimethamine 48 DPN 48 phenol 48 LTC4 45 more...

---