Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:APRD00345 (ICI)
 5,388 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study compares the efficacy in early pregnancy of prostaglandin (PG) F2alpha and PGF2alpha analogue, ICI 74,205 (racemic 20-ethyl-PGF2alpha). The study involved 19 patients of which 10 were treated with ICI 74,205 and 9 with PGF2alpha. The duration of amenorrhoea varied from 38-64 days. 2 patients in each group were found to be nonpregnant at the time of treatment. 6 patients received one analgesic injection and 4 required 2 injections. Follow-up was done at 5, 7, 10, 14, 21, and 30 days after treatment. Results were: 1) 7 pregnant patients receiving PGF2alpha aborted and 6 of the eight receiving ICI 74,205 aborted, 2) the two patients who failed to abort within 14 days were treated by conventional curettage, 3) the patients receiving PGF2alpha were assessed to have aborted more quickly than those receiving ICI 74,205, and 4) evacuation of the uterus was performed in 4 patients (for bleeding in 3 patients receiving ICI 74,205, and for suspected faulure in 1 treated with PGF2alpha). Vaginal blood-loss persisted for 5-21 days in patients in whom evacuation was not performed. 2 patients receiving ICI 74,205 and 4 receiving PGF2alpha vomited; all patients experienced moderate to severe uterine cramps. This study confirms the efficacy of the PGs in inducing early abortion. The side effects were a source of discomfort in most patients but blood-loss was not excessive.
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PMID:Letter: Early abortion induced with prostaglandin F2a and a prostaglandin analogue I.C.I. 74,205. 412 70

Studies with an emulsion formulation of ICI 35 868 (2,6- diisopropylphenol ) indicate that this new formulation has anaesthetic properties in rats and mice, and haemodynamic effects in the mini-pig which are similar to those of the previously available Cremophor formulation. Administration of the emulsion formulation to dogs produced no untoward effect, whereas the Cremophor formulation produced a marked increase in plasma histamine concentration. In the mini-pig, no adverse response was produced by the repeated administration of the emulsion formulation of ICI 35 868, whereas the Cremophor formulation produced anaphylactoid responses when a second injection was given 1 week after an uneventful first exposure to this formulation. Behavioural responses in the rat suggest that the emulsion formulation may produce less discomfort on i.v. injection.
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PMID:Pharmacology of an emulsion formulation of ICI 35 868. 620 10

In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg-1. Comparison of this dose with Althesin 0.05 ml kg-1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash reflex were 57 +/- SD 10.1 s (ICI 35 868) and 46 +/- 3.9s (Althesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.
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PMID:Preliminary experience with ICI 35 868 as an i.v. induction agent: comparison with althesin. 696 67

Seventy-six consecutive patients were studied prospectively in order to assess the value of suprapubic bladder drainage following surgery of the rectum and sigmoid colon. An Argyle-Ingram catheter (ICI) was inserted after the laparotomy incision had been made and the bladder was drained continuously for 24 h after which the catheter was closed and opened only every 6 h for 10 min. The patients were invited to void at will after the first 24 h. The catheter was removed when the post-voided volume became less than 50 ml on each of two subsequent measurements. The longest period of drainage was necessary after rectal excision, while rectosigmoid resections demanded shorter periods. The catheter did not function in one patient and urethral catheterization became necessary after removal of the suprapubic catheter in 4 patients. The method of suprapubic bladder drainage is recommended because it permits spontaneous voiding, allows measurement of residual volume without urethral instrumentation, gives little discomfort to the patient and has few complications.
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PMID:Suprapubic bladder drainage in colorectal surgery. 722 64