Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: DrugBank:APRD00080 (Leaf)
 21,685 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two rare cases of fusiform aneurysms of A1 segment of the anterior cerebral artery are reported. Case 1: A 62-year-old woman was admitted with sudden onset of severe headache and loss of consciousness, on August 22, 1982. CT scan showed subarachnoid hemorrhage at the basal cisterns. Left carotid angiography revealed a spindle shaped aneurysmal dilatation in the A1 segment of the anterior cerebral artery. Four-vessel angiography was performed twice but no other aneurysm was found. She was treated conservatively and the clinical course was not eventful. She was discharged with no neurological deficit one month after the admission. Case 2: A 49-year-old man complained of sudden onset of severe headache, nausea and vomiting on August 24, 1986. He was transferred to a local hospital and CT scan showed subarachnoid hemorrhage at the basal cisterns. Angiography revealed a fusiform aneurysm of the proximal anterior cerebral artery. He was referred to our hospital on the day of onset. He was operated on via bifrontal interhemispheric approach. The fusiform aneurysm of A1 segment was trapped successfully using temporary occlusion of A1 and A2 bilaterally under the administration of Sendai-Cocktail. V-P shunt was performed 1 week after the aneurysmal operation. The post-operative course was uneventful. He was discharged with no neurological deficit three months after operation. As far as we know, there are 6 cases of fusiform aneurysm of A1 segment of anterior cerebral artery in the literature. In this report, our two cases were described and treatment of such aneurysms were discussed.
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PMID:[Two cases of ruptured fusiform aneurysm of the proximal anterior cerebral artery (A1 segment)]. 267 74

A case of giant basilar artery aneurysm successfully treated utilizing balloon catheter under the administration of 20% mannitol, dexamethasone, vitamin E (Sendai Cocktail) is reported. The patient, 59 years old female, was admitted to our clinic with complaints of headache. CT scan revealed partially enhanced, round-shaped high density mass with a diameter of 35 mm in the left posterior part of the basal cistern. Vertebral angiography revealed aneurysm at the junction of left posterior cerebral artery and superior cerebellar artery. These findings indicate the partially thrombosed giant basilar artery aneurysm. Direct operation was performed just after the inflation of balloon within the aneurysm which made temporary occlusion of the aneurysm to make the operation safely. After removal of some amount of thrombosed aneurysm, temporary clips were applied on the basilar and bilateral posterior cerebral arteries, and then the neck of aneurysm was clipped. The combined use of the balloon, Sendai cocktail and temporary clips were recommended in such a case.
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PMID:[A successfully treated case of giant basilar artery aneurysm utilizing balloon catheter occlusion and brain protective substances]. 308 85

Inconsistencies within results of case-control studies on Alzheimer's disease risk factors led to a search of the literature for a potential cofactor. Reduced cerebral blood flow was selected and literature was surveyed for evidence of a cerebral blood flow linkage with the more than 40 putative risks. Alcohol abuse, depression, head trauma, underactivity, old age, sleep disturbance, glucose utilization, Down's syndrome, and Parkinson's disease are risk factors where an association with reduced cerebral blood flow is documented. Studies were cited showing that improved cerebral blood flow is associated with factors thought to be helpful in Alzheimer's disease, such as education or occupational attainment, exercise, headache, smoking, and arthritis/anti-inflammatory drugs to the extent that aspirin is used. Sugar consumption is identified as a potential risk factor with glucose management in Alzheimer's disease also shown to involve reduced cerebral blood flow. An hypothesis is developed showing how compromised regional cerebral blood flow could fit as a cofactor for genetic, autoimmune, and neurotoxic aspects of Alzheimer's disease.
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PMID:Alzheimer's disease risk factors as related to cerebral blood flow. 873 67

A 20-year-old previously healthy male presented at the pain clinic with chronic headache of about one year duration. Clinical examination revealed no pathological manifestations. During the consultation the patient was drinking Coca-Cola. On direct questioning he told that drinking Coca-Cola gave partial relief from the headache, and that the headache started after he had received two spinal anaesthetics for treatment of a lower leg fracture. Postural post dural puncture headache was now suspected and an epidural blood patch performed. Despite an interval of nearly 12 months since the dural punctures, a single epidural blood patch completely relieved the headache. This case history demonstrates that an epidural blood patch should be tried if a chronic post dural puncture headache is suspected.
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PMID:Relief of postural post dural puncture headache by an epidural blood patch 12 months after dural puncture. 1052 46

Three children, two girls aged 9 and 13 years and a boy aged 9 years, and a man aged 22, presented with headache of migrainoid character. The complaints resolved after attention had been given to sleeping habits, notably problems with falling asleep. The literature on the relationship between lack of sleep and headache is scarce. In history-taking doctors often neglect sleeping customs. Yet awareness of this connection can provide the clue to a successful treatment of headache. In more than half the children with headache who are referred to the outpatient clinic of Neurology, a serious lack of sleep is a major contributing factor to the problems. One should strongly advise against use of coffee and Cola drinks at all times and of tea in the evening. Patients are urged to create a restful atmosphere about bedtime: taking a walk or a hot shower, being told a story and so on. They should not read in bed, watch TV or play computer games in the bedroom. Prescription of clonidine 0.025-0.075 mg in children before bedtime may be useful.
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PMID:[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. 1062 59

Ocotea bullata (Lauraceae), one of the top-ten traditional medicinal plants used in KwaZulu-Natal, is close to extinction through high demand and destructive harvesting methods. The stem bark is traditionally used to cure headaches, urinary disorders and stomach problems. Substitution of leaves for bark provides a possible resource management solution for this threatened medicinal plant. One aim of this study was to compare the chemical composition of O. bullata leaves and bark using TLC, HPLC and GC-MS analysis. The characteristic analytical fingerprints of leaf and bark extracts showed great similarities. A second aim was to investigate the pharmacological properties of O. bullata as a remedy against headaches. Leaf and bark extracts were tested in terms of cyclooxygenase-1 and 5-lipoxygenase inhibition. Extracts from the bark exhibited moderate inhibitory activity in both test systems. Extracts from fresh leaves were superior to bark extracts in terms of their in vitro inhibitory activity against cyclooxygenase-1 and 5-lipoxygenase. Volatiles obtained from n-hexane extracts of leaves and bark showed better inhibitory activity towards cyclooxygenase-1 and especially towards 5-lipoxygenase than the original n-hexane extracts. Volatiles were therefore recognized as one of the main active principles in O. bullata with regards to the anti-inflammatory properties of this medicinal plant. This lends support to the traditional usage of O. bullata bark as an inhalant or snuff.
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PMID:Analytical and pharmacological investigation of Ocotea bullata (black stinkwood) bark and leaves. 1090 66

An epidemic of health complaints occurred in five Belgian schools in June 1999. A qualitative investigation described the scenario. The role of soft drinks was assessed by using a case-control study. Cases were students complaining of headache, dizziness, nausea, vomiting, abdominal pain, diarrhea, or trembling. Controls were students present at school on the day of the outbreak but not taken ill. An analysis was performed separately for school A, where the outbreak started, and was pooled for schools B-E. In school A, the attack rate (13.2%) was higher than in schools B-E (3.6%, relative risk = 3.6, 95% confidence interval (CI): 2.5, 5.3). Exclusive consumption of regular Coca-Cola (school A: odds ratio (OR) = 29.7, 95% CI: 1.32, 663.6; schools B-E: OR = 7.3, 95% CI: 2.9, 18.0) and low mental health score (school A: OR = 16.1, 95% CI: 1.3, 201.9; schools B-E: OR = 3.1, 95% CI: 1.5, 6.6) were independently associated with the illness. In schools B-E, consumption of Fanta, consumption of Coca-Cola light, and female gender were also associated with the illness. It seems reasonable to attribute the first cases of illness in school A to regular Coca-Cola consumption. However, mass sociogenic illness could explain the majority of the other cases.
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PMID:Belgian coca-cola-related outbreak: intoxication, mass sociogenic illness, or both? 1179 Jun 77

From 1959-1964 the incidence of puerperal sterilization was 3.5% at the Lady Hardinge Hospital in New Delhi, an increase over the incidence of 2.15% from 1952-1957. The group analyzed in this study consists of 301 women sterilized during the 1959-64 period. Sterilizations were postpartum (191), during caesarean section or hysterotomy (74), and miscellaneous (36, including post-abortion). Average age was 32.5; average parity was 6.0. The majority had at least 2 male children. Indications for sterilization were socioeconomic (90%), obstetric (7%), and medical (3.3%). Immediate postoperative sequelae, studied in the postpartum cases only, included pyrexia and sepsis at rates of 25% and 24% of postpartum women. The most common late sequelae among all the women were chronic fatigue (44%), menstrual disturbances (28.9%), headache (28%), backache (26.5%), and lower abdominal pain (27.5%). The high incidence of chronic pelvic inflammation, 15%, was probably associated with the use of silk sutures. 2 patients became subsequently pregnant; the pregnancy rate was thus an unsurprising 0.7%.
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PMID:A review of 301 cases of sterilisation. 1233 82

The internal contamination with depleted uranium (DU) isotopes was detected in British, Canadian, and United States Gulf War veterans as late as nine years after inhalational exposure to radioactive dust in the Persian Gulf War I. DU isotopes were also identified in a Canadian veteran's autopsy samples of lung, liver, kidney, and bone. In soil samples from Kosovo, hundreds of particles, mostly less than 5 microm in size, were found in milligram quantities. Gulf War I in 1991 resulted in 350 metric tons of DU deposited in the environment and 3-6 million grams of DU aerosol released into the atmosphere. Its legacy, Gulf War disease, is a complex, progressive, incapacitating multiorgan system disorder. The symptoms include incapacitating fatigue, musculoskeletel and joint pains, headaches, neuropsychiatric disorders, affect changes, confusion, visual problems, changes of gait, loss of memory, lymphadenopathies, respiratory impairment, impotence, and urinary tract morphological and functional alterations. Current understanding of its etiology seems far from being adequate. After the Afghanistan Operation Anaconda (2002), our team studied the population of Jalalabad, Spin Gar, Tora Bora, and Kabul areas, and identified civilians with the symptoms similar to those of Gulf War syndrome. Twenty-four-hour urine samples from 8 symptomatic subjects were collected by the following criteria: 1) the onset of symptoms relative to the bombing raids; 2) physical presence in the area of the bombing; and 3) clinical manifestations. Control subjects were selected among the sympotom-free residents in non-targeted areas. All samples were analyzed for the concentration and ratio of four uranium isotopes, (234)U, (235)U, (236)U and (238)U, by using a multicollector, inductively coupled plasma ionization mass spectrometry. The first results from the Jalalabad province revealed urinary excretion of total uranium in all subjects significantly exceeding the values in the nonexposed population. The analysis of the isotopic ratios identified non-depleted uranium. Studies of specimens collected in 2002 revealed uranium concentrations up to 200 times higher in the districts of Tora Bora, Yaka Toot, Lal Mal, Makam Khan Farm, Arda Farm, Bibi Mahro, Poli Cherki, and the Kabul airport than in the control population. Uranium levels in the soil samples from the bombsites show values two to three times higher than worldwide concentration levels of 2 to 3 mg/kg and significantly higher concentrations in water than the World Health Organization maximum permissible levels. This growing body of evidence undoubtedly puts the problem of prevention and solution of the DU contamination high on the priority list.
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PMID:Undiagnosed illnesses and radioactive warfare. 1451 7

Brucellosis is a common zoonotic disease transmittable to humans from infected animal reservoirs. Malta, Rock, Gibraltar, Cyprus or Mediterranean fever, Bang's disease, intermittent typhoid or typho-malarial fever, undulant fever, etc. are just various synonyms for brucellosis. Patients suffering from this disease show unspecific symptoms, e.g. fever, chills, malaise, arthralgia, headache, tiredness and weakness. Human brucellosis may be caused by four of totally six genetically and phenotypically closely related Brucella species, i.e. B. melitensis, B. abortus, B. suis and B. canis. Although many organ systems may be involved, brucellosis is rarely fatal. Therapeutic failure and relapses, chronic courses and severe complications like bone and joint involvement, neurobrucellosis and endocarditis are characteristic for the disease. A definite diagnosis requires the isolation of Brucellae from blood, bone marrow or other tissues. However, cultural examinations are time-consuming, hazardous and not sensitive. Thus, clinicians often rely on the indirect proof of infection. The detection of high or rising titers of specific antibodies in the serum allows a tentative diagnosis. A variety of serological tests has been applied, but at least two serological tests have to be combined to avoid false negative results. Usually, the serum agglutination test is used for a first screening and complement fixation or Coombs' test will confirm its results. As Brucella ELISAs are more sensitive and specific than other serological tests, they may replace them step by step. This review will summarize advantages and disadvantages of the serological techniques used in clinical laboratories for indirect verification of human brucellosis.
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PMID:Laboratory-based diagnosis of brucellosis--a review of the literature. Part II: serological tests for brucellosis. 1465 29


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