Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:80-08-0 (DSS)
 2,544 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using immunoblotting, the antigenic structure of 6 Leishmania strains has been studied: 1) MHOM/IN/80/DDS--Leishmania (Leishmania) donovani; 2) MHOM/SU/63/VL--L. sp. ZMA; 3) MHOM/SU/73/K-27--L. tropica; 4) MHOM/SU/73/5Ash--L. major; 5) MHOM/GE/84/H-132--L. mexicana amazonensis; 6) REPT/SU/83/3960-GC--L. (Sauroleishmania) gymnodactyli. Antigens of Leishmania surface membranes and rabbit antisera against them have been used. Among the agents of leishmaniasis in the Old World (1-4), the most intensive antigenic lines were found in the medium and high-molecular mass area (43-200 kD). In L. (L) mexican a amazonensis (5) species-specific lines have been identified in 10-22 kD area, which is indicative of considerable antigenic differences in Leishmania of the Old and New Worlds. The most marked antigenic differences from other types were noted in L. (S) gymnodactyli (6). It was characterized by the absence of antigenic bands in the medium and high molecular mass areas, the lines associated with species-specific determinants located in the low molecular mass area (18 and 25 kD). The results of cross-reacting c-ELISA using the same antigens and antisera correlated well with the above data of immunoblotting. Immunoblotting may be used for identification of species-specific antigenic structures which may be helpful in serological tests for more accurate leishmania identification and leishmaniasis diagnosis.
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PMID:[Immunoblotting in the study of the antigenic structure of Leishmania]. 229 Mar 97

From a series of thirty six 2,3, N-substituted 4,4'-diaminodiphenyl sulphones studied for their suppressive activity in mice against blood induced erythrocytic stage of Plasmodium berghei infection, six sulphones (1-6) showed 100% suppressive and curative activity at an intraperitoneal dose of 1 mg/kg x 4 days. These sulphones have been studied for their suppressive activity in still lower doses ranging from 1.0-0.25 mg/kg i.p. x 4 days and for their curative activity at 1 mg/kg i.p. x 4 days in comparison to DDS as standard drug. The maximum tolerated dose of these compounds and DDS has also been determined. These sulphones have better therapeutic efficacy for their suppressive and curative action than DDS.
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PMID:Antimalarial activity of some 4-alkylamino 2/3 methoxy-4-aminodiphenyl sulphones. 229 20

The sophisticated cities, the ancient culture, splendid hotels, wonderful beaches, the variety of food, the beautiful people, the predictable climate and above all the smiling friendliness of the Thais make up some of the exotic attractions extolled by Thailand's tourist industry. For the last 8 years, through the good offices of British Council, several British academics have appreciated all that but have also had the privilege of working alongside Thai colleagues in a much more down-to-earth mode. In 1980 the Thai Government decided that a dental faculty with a target output of 40 DDS graduates per annum should be set up at the Prince of Songkhla University at Hadyai, a town of some 100,000 inhabitants about 1000 km south of Bangkok near the Malaysian border. The university itself is modern, situated on a splendid campus and has a well-established medical faculty. At that time, there were, in Thailand, four dental faculties: two in Bangkok, one in Chiang Mai and one at Khon Kaen. Prince of Songkhla was to be the fifth.
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PMID:Prince of Songkhla--a new dental faculty. 236 Oct 77

Smear layers are very soluble in acidic solutions. Removal of smear layers increases dentin permeability and the potential for pulpal irritation. In this study, smear layers were treated with either saline, Barrier, Copalite, LC-Scotchbond, Hydroxyline, or DDS 1 & 2 to determine how well they protected the dentin from subsequent acid attack with 37% phosphoric acid for two minutes. Using both SEM and permeability measurements, the materials were ranked from least to most effective as: Saline less than Barrier = Copalite less than Hydroxyline = Scotchbond = DDS 1 & 2.
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PMID:Protective effects of cavity liners on dentin. 236 41

The feasibility and effects of a 3-year treatment using rifampicin (RFP), clofazimine (B663) and dapsone (DDS) in multibacillary leprosy patients in Yangzhou Prefecture and Dongtai County (1983-1986) are reported. Among 591 active multibacillary leprosy patients in the two areas, 569 (96.30%) were treated with this regimen. Of 303 cases available for analysis, 196 (64.7%) cases showed negative skin smears and clinical inactivity. The rest showed different degrees of improvement. The average reduction of BI was 0.78. The intensity and frequency of ENL and neuritis decreased markedly with treatment. The main side-effects were pigmentation and ichthyosiform changes of the skin, but these did not influence treatment.
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PMID:Effect of three-year multidrug therapy in multibacillary leprosy patients. 237 Dec 63

Airway reactivity and disease severity were investigated in 24 subjects with stable chronic bronchial asthma. Disease severity was determined by assigning a disease severity score (DSS) representing six clinical and therapeutic parameters. Airway hyperresponsiveness was assessed in two ways: airway reactivity score (ARS) based on the number of positive responses to a question concerning exposure to 22 nonspecific inhaled irritants and methacholine challenge testing and determining the cumulative dose causing a 20% reduction in FEV2 (CMD20). A significant correlation between DDS and CMD20 (r = 0.57; p less than 0.003) and DSS and ARS (r = 0.67; p less than 0.0003) attested to the important influence of airway hyperresponsiveness on disease severity. Significant correlations for ARS with CMD20 (r = -0.60; p less than 0.002) suggested the consistency with which the ARS estimated methacholine hyperresponsiveness. We found no statistically significant correlations between DSS, ARS, or CMD20 and the age of subject, duration of asthma, or other host characteristics. There was not a significant correlation between the degree of airway obstruction and DSS or ARS noted. The results of this investigation demonstrate the value of the use of clinical information for assessing airway hyperresponsiveness and disease severity in patients with chronic stable asthma. Both ARS and DSS are useful clinical tools for estimating methacholine reactivity.
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PMID:Assessment of airway hyperresponsiveness in chronic stable asthma. 240 41

The administration of an Elemental Diet to 5 patients with dermatitis herpetiformis, requiring high doses of Dapsone (diaminodiphenylsulfone, DDS), showed a rapid and beneficial effect on the skin lesions within two weeks. This effect was not influenced by simultaneous gluten challenge in one patient. A possible explanation is a reduction in the amount of harmful immune complexes due to the elimination of proteins from the diet. Subsequent introduction of a more comprehensive diet led to an increase of the minimal effective dose of Dapsone. These results underline the importance of dietary influences on the skin activity in dermatitis herpetiformis, other than gluten alone.
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PMID:Dermatitis herpetiformis: consequences of elemental diet. 243 Apr 2

Serotonin is N-acetylated to melatonin. The purpose of this study was to explore the possibility of N-acetylation of dapsone reflecting serotonergic activity. The ratio of monoacetyldapsone/dapsone (MAD/DDS) in plasma, 5-HIAA in CSF, and imipramine-binding to platelets were investigated in a group of psychiatric patients, diagnosed according to the DSM-III as affective disorders, schizophrenia, and personality disorders. There was no significant correlation between either of the serotonergic estimates and N-acetylation in the whole patient group or in diagnostic subgroups of patients. Sixty-four percent of the patients were slow N-acetylators (MAD/DDS less than 0.4), which is a ratio in line with several other studies of psychiatric patients. Among patients with affective disorders, all unipolar patients were slow N-acetylators, while five out of six bipolar patients were fast N-acetylators. The N-acetylation of patients with a history of suicide attempt did not differ from those without. The discrepancy in N-acetylation between uni- and bipolar patients might again address the issue of them representing two different biochemical and genetic disorders.
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PMID:N-acetylation and serotonergic measures in a group of psychiatric patients. 245 92

The inhibitory effects by the combined doses of bacteriostatic DDS and several immunostimulants on the growth of leprosy bacilli (LB) inoculated into the footpads of nude mice were examined, using a strain of hybrid nude mice named Jcl:AF-nu, which is resistible to infections more than strain BALB/c-nu. The results found were: 1. LB could proliferate up to 10(9) level in the footpads of this strain of hybrid nude mice. 2. The combined dose of muramyl dipeptide (MDP) or a water-soluble lipoidal amine, CP-46665 and DDS mixed with chow in the content ratio of 0.005% completely inhibited the growth of LB. Whereas, the growth inhibition by DDS alone was only partial. 3. A derivative of MDP, muroctasin could partially inhibit the growth of LB without combined dose of DDS. 4. The combined dose of an antitumor beta-1, 3-glucan named ATSO could not enhance the partial growth inhibition due to the dose of DDS through 0.005%-DDS chow. Based on these results, the possibility of Jcl:AF-nu mice as a favorable animal model for examining the synergic inhibitory effect on the growth of LB due to the combined dose of an antileprous chemotherapeutic and an immunostimulant was discussed.
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PMID:The inhibitory effects by combined doses of DDS and several immunostimulants on the growth of leprosy bacilli inoculated into footpads of hybrid nude mice, Jcl:AF-nu. 248 82

Photosensitivity as an adverse reaction to DDS was recognized in 6 patients of our hospital during the summer of 1988. The clinical manifestations and also the management of those patients are given in detail. All doctors and health workers involved with leprosy need to be aware of such a problem and to take correct decisions after weighing the risk of photosensitivity against the potential benefit of DDS.
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PMID:DDS-induced photosensitivity with reference to six case reports. 257 Mar 35


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