Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: CAS:71324-20-4 (
MHPG-sulfate
)
6
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To elucidate the influence of total sleep deprivation (TSD) on catecholaminergic neurotransmission, which is assumed to be disturbed in depression, 9 depressive patients collected consecutive 24-h urine samples prior to (baseline), during (TSD) and following total sleep deprivation (post-TSD). Urine samples were analysed for total MHPG (3-methoxy-4-hydroxyphenylglycol), conjugates of MHPG (glucuronide and sulfate), excretion of HVA (homovanillic acid) and
VMA
(
3-methoxy-4-hydroxymandelic acid
). TSD increased the urinary excretion of
MHPG-sulfate
as a marker of the central norepinephrine metabolism and the excretion rates of
VMA
and HVA as indices of the peripheral catecholamine metabolism. Patients with higher
VMA
values prior to TSD reacted worse, and the
VMA
increase due to TSD was positively correlated with the response. The results demonstrate that TSD, besides acting as a stimulus on the peripheral sympathetic nervous system, influences central nervous noradrenergic neurotransmission, as reflected by the increase of
MHPG-sulfate
.
...
PMID:The influence of total sleep deprivation on urinary excretion of catecholamine metabolites in major depression. 839 44
