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Compound
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Gene/Protein
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Target Concepts:
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Query: CAS:696-29-7 (
isopropylcyclohexane
)
7
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The metabolism of
isopropylcyclohexane
and associated renal pathology were evaluated in male Fischer 344 rats exposed by oral gavage. The rats experienced moderate proximal tubular damage similar to that produced by acyclic, branched-chain hydrocarbons. The urinary metabolites of
isopropylcyclohexane
included cis-4-isopropylcyclohexanol, trans-4-isopropylcyclohexanol, 2-cyclohexylpropanoic acid, 2-cyclohexyl-
1,3-propanediol
, 2t-hydroxy-4t-isopropylcyclohexanol, 2c-hydroxy-4c-isopropyl-cyclohexanol, and 2c-hydroxy-4t-isopropylcyclohexanol. The extent and preferred sites of oxidative metabolism of nephrotoxic hydrocarbons could potentially prove useful in elucidating the pathogenic mechanisms.
...
PMID:Metabolism of nephrotoxic isopropylcyclohexane in male Fischer 344 rats. 337 63
