Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:59-42-7 (Phenylephrine)
 1,361 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the surgery two patients with Posner-Schlossmann-Syndrome were observed for several months. The therapy of the acute attack secondary glaucoma was the combination of Diamox, Cortison - and Neosynephrine eye-drops. With Pilocarpine the I.O.P. lowering was insufficient. In one case corneal precipitates typical for Heterochromia complicata Fuchs were observed.
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PMID:[The treatment of posner-schlossmann's syndrome. (acute glaucomatocyclitic crises) (author's transl)]. 124 97

The secretory response of dispersed rat submandibular cells as it relates to the net efflux of K+ following sympathomimetic and parasympathomimetic stimulation was evaluated. The cholinergic agonists acetylcholine and carbamylcholine were found to have equal efficacy but dissimilar receptor affinity. Median effective concentrations (EC50's) were 1.7 x 10(-7) M and 7.1 x 10(-7) M, respectively. Pilocarpine was found to be acting as a "partial" agonist and had an EC50 at 5.6 x 10(-7) M. (-)-Norepinephrine and (-)-epinephrine were found to have similar efficacy and potency with EC50's at 5.6 x 10(-7) M and 3.8 x 10(-7) M, respectively. (-)-Phenylephrine was found to act as a partial agonist with an EC50 at 3.8 x 10(-6) M, whereas (-)-isoproterenol stimulation resulted in no net K+ efflux within the concentrations tested (10(-8) M--10(-3) M). Extracellular Ca2+, but not Mg2+, was shown to be required to elicit a net K efflux following either cholinergic or alpha-adrenergic stimulation.
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PMID:Secretory response of dispersed rat submandibular cells. I. Potassium release. 610 45

Long-term therapy using a combination of Pilocarpine and Phenylephrine in three different concentrations is described. The trial was carried out in the form of a multi-center study by general practitioners and showed the constant effect over lengthy periods of time, with no signs of tachyphylaxis or an increase in effect, which would have pointed to an increase in the effective level. The number of side-effects is minimal, due to the submaximal doses used.
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PMID:[Bivalent-vegetative long-term therapy with glauko biciron (author's transl)]. 723 Jun 78

1. During heat exposure, rats secrete large amounts of saliva. Salivation started when body temperature exceeded 39 degrees C and was reduced by kininogen deficiency or by HOE 140, a bradykinin antagonist. This secretory response was associated with a partial depletion of glandular kallikrein from the submaxillary glands. The depletion was abolished by simultaneous treatment of the animals with an alpha- and a beta-adrenergic antagonist. During heat exposure, plasma levels of kininogens were reduced. 2. Pilocarpine and substance P induced a similar flow of saliva in normal and kininogen-deficient rats and released low amounts of kallikrein from salivary glands. Phenylephrine and isoproterenol induced a larger flow of saliva in normal rats than in kininogen-deficient rats. Both agents released large amounts of kallikrein in saliva but isoproterenol was only active at large doses. 3. During heat exposure, the blood content of submaxillary glands in normal as well as in kininogen-deficient rats increased as a function of the ambient temperature. This increase was suppressed by atropine and NG-nitro-L-arginine, a NO-synthase inhibitor, but was not modified by HOE 140. Simultaneously, a swelling of the glands and of the surrounding soft tissues occurred in normal but not in kininogen-deficient rats. Kallikrein was present in the edema fluid. 4. The kallikrein-kinin system would thus participate in heat-induced salivary secretion and kinins may be a factor responsible for electrolyte and water exchanges in the glands.
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PMID:Involvement of the kallikrein-kinin system in the salivary secretion elicited in rats by heat stress. 753 74