Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:40776-52-1 (C20H30O3)
 4 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Euniciniatin [4(S),7(R)-epoxy-3(R)-hydroxy-1(R),11(S) -dolabella-8(Z),12(18)-dien-13-one; (1R,3R,4S,7R,11S) -3-hydroxy-12-isopropylidene-15-oxa-1,4,8-trimethyltricyclo [9.3.0.1(4,7)]pentadec-8(Z)-3n-13-one], C20H30O3, was synthesized from a known dolabellane constituent of E. laciniata, namely, dolabellatrienone. The structure of this compound has a trans-bicyclo[9.3.0]tetradecane nucleus containing an additional 4,7-oxa bridge. The three O atoms in the molecule all belong to different functional groups, i.e. one is part of an ether bridge [O(3)-C(4) 1.452 (5) and O(3)-C(7) 1.429 (5) A], one an alcohol [O(2)-C(3) 1.429 (6) A] and one a ketone [O(1)-C(13) 1.233 (5) A].
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PMID:Euniciniatin. 909 95

The methanol extract of Brazilian propolis was fractionated by HPLC, based on HuH13 (human hepatocellular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H30O3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-17-oic acid).
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PMID:Isolation and characterization of cytotoxic diterpenoid isomers from propolis. 937

The title compound, 2-[1,2,3,4,4a,4b,5,6,7,8,8a,9-dodecahydro-7-hydroxy-4b,8,8-trimethylphenanthren-2-yl]propenoic acid, C20H30O3, is a naturally occurring diterpenoid which was isolated from Rabdosia macrocalyx. The hydroxy and carboxy groups, which are located at the two ends of the molecule, both serve as simultaneous hydrogen-bond donors and acceptors. Two intermolecular O-H...O hydrogen bonds are present and link each molecule to four neighbours, thus forming an extensive hydrogen-bond network within the crystal.
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PMID:Macrocalyxin I. 1178 96

The title compound, C20H30O3, is a new functionalized perhydrotriphenylene derivative formed via a tandem Michael addition-aldol reaction. The structural study reveals that the system of fused rings approximates a C2 point symmetry, with trans-cis-cis ring junctions, while highly symmetric all-trans perhydrotriphenylene, previously characterized, approximates a D3 symmetry. The perhydrotriphenylene nucleus of the title compound corresponds to the third stable stereoisomer isolated for this polycyclic system. Considering that the C(s) isomer was obtained recently through a similar tandem reaction, a general strategy is proposed which may help to obtain other stable stereoisomers of perhydrotriphenylene.
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PMID:rac-9-ethyl-12a-hydroxytetradecahydrotriphenylene-1,5(2H,4bH)-dione: stabilization of a new isomer of a functionalized perhydrotriphenylene through a tandem Michael addition-aldol reaction. 1853 39