Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:31879-05-7 (Fenoprofen)
 52 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pyrolysis gas chromatography mass spectrometry of Ibuprofen, Fenoprofen, Naproxen and Ketoprofen, a series of anti-inflammatory propionic acid derivatives, is shown to proceed via decarboxylation and elimination to yield characteristic ethyl and vinyl fragments. The pyrogram enables the identification of the drug to be achieved as the pure compound, in a formulated dosage form or excreted in urine. The presence of metabolites derived from Ibuprofen causes four new fragments to be observed in the urine pyrogram. The identification of 16 components of the control urine pyrogram is presented.
Biomed Mass Spectrom 1978 Dec
PMID:The identification of ibuprofen and analogues in urine by pyrolysis gas chromatography mass spectrometry. 74 36

Reversed-phase high-performance liquid chromatographic assays have been developed to quantitate simultaneously fenoprofen and its major metabolites as well as to distinguish between their R- and S- enantiomers following a single oral dose of 600 mg racemic fenoprofen to healthy volunteers. The compounds are extracted from plasma (after precipitation of plasma protein) or assayed directly in diluted urine samples employing a gradient solution on a C18 column and ultraviolet detection. Two internal standards, ketoprofen and flunoxaprofen, are used to allow measurement of very low (0.05 microgram/ml) and high (70 microgram/ml) concentrations in each sample. R- and S-fenoprofen glucuronides can be separated directly; the 4'-hydroxyfenoprofen conjugates are measured via an indirect method by comparing the concentration of 4'-hydroxyfenoprofen before and after hydrolysis. The R- and S-enantiomers of both parent and 4'-hydroxy metabolite are derivatized with L-leucinamide via an ethyl chloroformate intermediate and subsequently analyzed on a C18 column. Concentrations of metabolites found in plasma were low when compared to parent drug. The S/R ratio of fenoprofen in plasma always exceeds 1 and increases with time after dosage while the S/R ratio of its 4'-hydroxy metabolite remains almost unchanged at 1.1. R-Fenoprofen glucuronide disappears rapidly from plasma as compared to its S-antipode; a less pronounced difference is noted between R- and S-4'-hydroxyfenoprofen conjugates. Fenoprofen is almost completely excreted as its S-acyl glucuronides; the renal clearance of unchanged drug is very low.
J Chromatogr 1990 Dec 14
PMID:Stereoselective analysis of fenoprofen and its metabolites. 209 99

The title aldehyde, C15H14O3, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. Six significant intermolecular C-H...O interactions have C...O distances ranging from 3.405 (2) to 3.802 (2) A and C-H...O angles ranging from 121 to 162 degrees. These six intermolecular interactions link a molecule directly to six neighbors and form a three-dimensional network. The dihedral angle between the best-fit planes of the benzene rings within a molecule is 78.1 (1) degrees. The dihedral angle between the carboxaldehyde-group plane and the best-fit plane of the ring to which it is attached is 3 (1) degrees.
Acta Crystallogr C 1999 Dec 15
PMID:Network of C-H...O interactions in 4-benzyloxy-3-methoxybenzaldehyde (vanillin benzyl ether). 1064 Dec 85

Racemic threo-3-hydroxy-2,3-diphenylpropionic acid, C15H14O3, (I), crystallizes from ethyl acetate as a conglomerate of separate (+)- and (-)-crystals. The geometries of (I) and its methyl ester are compared. Reduction of (I) gives threo-1,2-diphenyl-1,3-propanediol. The synthesis of threo forms of 1,2-diaryl-1,3-propanediols via 2,3-diaryl-3-hydroxypropionic acids is discussed.
Acta Crystallogr C 2006 Dec
PMID:2,3-Diaryl-3-hydroxypropionic acid intermediates in the synthesis of threo forms of 1,2-diaryl-1,3-propanediols. 1714 12

Serotonin was linked by amidation to the carboxylic acid groups of a series of structurally diverse NSAIDs. The resulting NSAID-serotonin conjugates were tested in vitro for their ability to inhibit FAAH, TRPV1, and COX2. Ibuprofen-5-HT and Flurbiprofen-5-HT inhibited all three targets with approximately the same potency as N-arachidonoyl serotonin (AA-5-HT), while Fenoprofen-5-HT and Naproxen-5-HT showed activity as dual inhibitors of TRPV1 and COX2.
Bioorg Med Chem Lett 2014 Dec 15
PMID:Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates. 2546 64

Pharmaceuticals and Personal care products (PPCPs) are often found in effluents from wastewater treatment plants (WWTPs) due to insufficient removal during wastewater treatment processes. To understand the factors affecting the removal of PPCPs in classical activated sludge WWTPs, the present study was performed to assess the removal of frequently occurring pharmaceuticals (Naproxen, Fenoprofen, Ketoprofen, Dichlofenac, Carbamazepine) and the biocide Triclosan in activated sludge from four different Danish WWTPs. The respective degradation constants were compared to operational parameters previous shown to be of importance for degradation of micropollutants such as biomass concentration, and sludge retention time (SRT). The most rapid degradation, was observed for NSAID pharmaceuticals (55-90% for Fenoprofen, 77-94% for Ketoprofen and 46-90% for Naproxen), followed by Triclosan (61-91%), while Dichlofenac and Carbamazepine were found to be persistent in the systems. Degradation rate constants were calculated as 0.0026-0.0407 for NSAID pharmaceuticals and 0.0022-0.0065 for triclosan. No relationships were observed between degradation rates and biomass concentrations in the diverse sludges. However, for the investigated PPCPs, the optimal SRT was within 14-20 days (for these values degradation of these PPCPs was the most efficient). Though all of these parameters influence the degradation rate, none of them seems to be overall decisive. These observations indicate that the biological composition of the sludge is more important than the design parameters of the respective treatment plant.
Ecotoxicology 2015 Dec
PMID:Degradation of PPCPs in activated sludge from different WWTPs in Denmark. 2640 12