Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: CAS:25874-48-0 (2-fluorophenylalanine)
 4 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amino acid-requiring mutants capable of producing derepressed levels of aspartate transcarbamylase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2) were obtained and used for the incorporation in this enzyme of eight different amino acid analogs. These amino acid replacements enabled the biosynthesis of a series of modified aspartate transcarbamylases altered in their catalytic or regulatory properties. The enzyme in which phenylalanine was rereplaced by 2-fluorophenylalanine was purified to homogeneity and appeared to have the same specific activity as normal asparate transcarbamylase but lacking both homotropic and heterotropic interactions.
Biochim Biophys Acta 1980 Sep 09
PMID:Incorporation of amino acid analogs during the biosynthesis of Escherichia coli aspartate transcarbamylase. 700 Jan 92