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Query: CAS:151-18-8 (BAPN)
 130 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

beta-Aminopropionitrile, a lysyl oxidase and collagen cross-linkage inhibitor, resulted in a 0.90 diopter or 20% enhancement of radial keratotomy in rabbits.
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PMID:Enhancement of radial keratotomy by chemical inhibition of collagen cross-linkages: a preliminary report. 666 Jul 29

This study assessed the effect of beta-aminopropionitrile treatment on the long-term curvature and compliance of corneal tissue subjected to radial keratotomy (RK). beta-Aminopropionitrile is known to inhibit cross-linking of collagen and is expected to enhance the flexibility of scar tissue, thereby reducing wound contracture and regression after RK. Seventeen adult New Zealand rabbits, weighing about 4.5 kg each, underwent RK in both eyes (eight incisions, 90% deep, 3-mm pupillary zone). Their mean preoperative corneal curvature was 44.25 diopters (+/- 0.32D at 95% confidence level). Nine of the rabbits were treated topically with beta-aminopropionitrile ointment (33 weight % in petroleum three times daily), while the control group received the petrolatum base only. The remainder of the animals received bland petrolatum gel as a control. The animals were given periodic keratometric examinations and were killed after six to eight weeks. At that time, the beta-aminopropionitrile group showed a mean reduction of 1.85 +/- 0.13 D in corneal curvature, compared with 1.18 +/- 0.08 D in the control group. The compliance and strength of the corneas were measured in vitro immediately after death. In the pressure range from 10 to 40 mm Hg, the beta-aminopropionitrile-treated corneas changed in curvature by an average of 1.4 D as compared with 0.5-D flattening for the controls. These results indicate the effectiveness of beta-aminopropionitrile treatment in enhancing longterm compliance and reducing refractive regression after RK.
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PMID:Effects of topical treatment with beta-aminopropionitrile after radial keratotomy in the rabbit. 669 78

BAPN-induced osteolathyrism in young and older male rats was examined for its responses to parathormone-free, gel-filtered bovine parathyroid extract (extract P) and to glutaurine (gamma-L-glutamyl-taurine), the latter being a hitherto unknown putative hormone isolated from bovine parathyroid and reproduced by synthesis. In case of the daily administration of 20 mg BAPN + 0.2 mg extract P/100 g body weight and of 40 mg BAPN + 0.2 micrograms glutaurine/100 g body weight, both substances were found to attenuate the manifestations of osteolathyrism, to a significant extent, without, however preventing their development completely. The significantly decreased Ca, P, chondroitine sulphate and chrondroprotein values due to the administration of BAPN showed a significant, or highly significant, increase for the cartilage in response to extract P, and for both cartilage and bone in response to glutaurine, without however, attaining the control values. Additional evidence has been furnished by the present study that synthetic glutaurine is equal to the parathormone-free, gel-filtered parathyroid extract (extract P) in its attenuating effect on experimental osteolathyrism.
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PMID:Effect of parathyroid extract and of glutaurine (gamma-L-glutamyl-taurine) on the manifestations of osteolathyrism. 677 40

beta-Aminopropionitrile (beta-APN), a lathyrogen, alters the physical characteristics of fibrous scar tissue and as such may have potential clinical use in treatment of injured spinal cord and peripheral nerve by reducing the physical barrier to axon regeneration. For beta-APN to exert its lathyrogenic effect, it must permeate the injury site and gain access to the developing collagenous scar. To investigate the diffusion characteristics, beta-[14C]APN solution was applied as an immersion bath to rat sciatic nerve using both in vivo and in vitro preparations for intervals of 15 to 90 min. The four experimental groups studied were (a) intact nerve, (b) hemisected nerve, (c) nerve with epineurium removed, and (d) nerve with both epineurium and perineurium removed. The isotope labeling index determined by autoradiography and scintillation counting indicated the perineurium as the primary barrier to significant diffusion of beta-APN in normal nerve. When perineurium was incised or removed, beta-APN entered the endoneurial matrix. beta-APN concentration in the epineurium and perineurium increased with increasing bathing time in vitro; but it decreased markedly after 15 min of in vivo bathing. These findings indicate that topical application of beta-APN to injured peripheral nerve would be a successful method of exposing fibrogenic intraneural tissue to the inhibitory effect on lysyl oxidase enzymes. Continuous application, however, will be necessary because of the rapid beta-APN removal documented in the vivo preparation.
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PMID:Diffusion characteristics of beta-aminopropionitrile in peripheral nerve. 682 64

The administration of lathyrogenetic agents (BAPN) at weak and prolonged doses (9 weeks, 1 g/kg/day) induced in the rat simultaneous alterations of aortic and cutaneous connective tissues comparable to the modifications observed during ageing in man. The lathyrogens produced this effect by inhibiting lysine-oxydase, the enzyme responsible for cross-linking collagen and elastin which leads to an increase in extractable collagen in the tissues. But BAPN did not appear to affect synthesis of collagen either in amount or in types I and III collagen ratio.
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PMID:[Lathyrism and collagens I and III (author's transl)]. 704 73

beta-Aminopropionitrile (beta APN), 500 ng/g body weight was injected intraperitoneally into male rats every 2 days between 2 and 28 days after birth. The lungs were examined structurally and functionally and compared with the lungs of control animals given injections of saline and 28-day-old normal male rats which were not given injections. Lungs volumes, both distended with air at 30 cm H2O and with formalin at 25 cm H2O, were increased in beta APN-treated animals. The architecture of the lung was altered so that there was a large increase in the "core," or air internal to the alveoli of the walls of alveolar ducts and sacs. Animals given injections of beta APN had 40--56% fewer alveoli than those given saline injections and normal animals. Experimental animals had larger alveoli. The lungs or beta APN- treated animals were hypercompliant, and their pressure-volume curves were shifted upward and to the left. There were morphologic changes in collagen and elastic tissue, which were more apparent in the elastic tissue. Since beta APN interferes with the synthesis of elastin and collagen, it appears that alterations in the collagen--elastin network reduces alveolar multiplication in the postnatal period. Control animals given saline had abnormal lungs when compared with normal animals. Their alveoli were larger, and they had fewer alveoli per unit volume. Thus the lung may be sensitive to relatively minor insults in the postnatal period.
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PMID:The effects of beta-aminopropionitrile on the growing rat lung. 744 13

beta-Aminopropionitrile (beta APN) was administered intraperitoneally to rats on postnatal days 1, 3, and 5. Body weight, lung volume, lung weight, number of alveoli per unit area and volume, total number of alveoli in the lung, and the total length of elastic fibers in the lung decreased, and the average alveolar volume increased in comparison with control animals similarly treated with saline. From Day 2 of age to Day 6 the total length of elastic fibers increased in control lungs but remained almost the same following beta APN treatment. Ultrastructurally, both the quality and quantity of elastin in lung alveolar wall were affected. beta APN also inhibited the synthesis of deoxyribonucleic acid in interstitial, endothelial, and Type II epithelial cells of the lung alveolar wall. The diminished number of alveoli gives support to the hypothesis that the elastin-collagen network may play a key role in postnatal alveolar multiplication.
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PMID:The effect of beta-aminopropionitrile on lung development in the rat. 744 14

Fibroblast cultures were readily propagated from fetal bovine ligamentum nuchae. The ligament cells were easily cultured by standard techniques and were maintained in culture flasks for up to 57 days. During this time they accumulated an extensive extracellular matrix which contained the main structural elements of the parent tissue, namely collagen and elastic fibres. Elastogenesis was seen to proceed in two phases: the formation of parallel bundles of 10--12 nm wide microfibrils followed by the deposition within these bundles of amorphous elastin-like material. Elastic fibres were not produced in cultures that were supplemented with ascorbic acid either in the absence or presence of the lathyrogen BAPN.
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PMID:An ultrastructural study of fibroblasts derived from bovine ligamentum nuchae and their capacity for elastogenesis in culture. 746 5

In the rat, prolonged administration (7 months) of Beta-Aminopropionitrile in association with a hyperlipidic diet caused the formation of widespread pronounced atheroma. The addition of Pyridinol Carbamate during the treatment minimized and retarded the appearance of lipid overload lesions. The histological modifications were found together with an increase in the free cholesterol fraction. These two observations explain the protective role of Pyridinol Carbamate on the wall of the aorta.
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PMID:Long term lathyrism and atherogenic diet in the rat. Protective action of pyridinol carbamate. 746 16

The fibrillar collagen network is postulated to be a primary determinant of left ventricular diastolic stiffness. This hypothesis was tested by examining the structural and physiological effects of a reduction in fibrillar collagen content and cross-linking in the intact left ventricle. Collagen cross-linking was inhibited by treating five normal adult pigs with beta-aminopropionitrile (BAPN; 10 g/day po) for 6 wk; five normal untreated pigs served as controls. Left ventricular volume, mass, and function were determined by simultaneous echocardiography and catheterization. Chamber stiffness, defined by pressure vs. volume data, and myocardial stiffness, defined by stress vs. dimension data, were determined from variably loaded beats during dextran infusion. Collagen distribution (% area) and integrity (% confluence) were determined by light microscopy. Collagen content was measured by hydroxyproline assay, and collagen cross-linking was measured by salt extraction. BAPN decreased collagen distribution (% area decreased from 12 +/- 1% in control to 7 +/- 1% in BAPN, P < 0.05), collagen integrity (% confluence decreased from 8 +/- 1% in control to 4 +/- 1% in BAPN, P < 0.05), collagen content (from 36 +/- 2 mg/g dry wt in control to 27 +/- 2 mg/g dry wt in BAPN, P < 0.05), and collagen cross-linking (extractable collagen increased from 21 +/- 2% in control to 28 +/- 2% in BAPN, P < 0.05). BAPN decreased chamber stiffness (0.13 +/- 0.02 in control to 0.06 +/- 0.01 in BAPN, P < 0.05) and myocardial stiffness (10.4 +/- 0.5 in control to 6.6 +/- 0.5 in BAPN, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. 757 29


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