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Query: CAS:142-82-5 (heptane)
 3,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of organic solvents on the stability and catalytic activity of the microbial lipase from Candida rugosa for hydrolysis of triglyceride (fat splitting) has been examined. The solvents examined were 5 hydrocarbons (n-hexane, n-heptane, n-octane, iso-octane and cyclohexane) and 3 ethers (diethyl-ether, diisopropylether and di-n-butylether). The results revealed that iso-octane and cyclohexane are superior to the other solvents examined for enzymatic fat splitting in organic solvent systems.
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PMID:Effects of organic solvents on lipase for fat splitting. 652 14

The distribution pattern of the protein on the surface of low density lipoproteins (LDL) of blood plasma was studied by quantitative estimation of the efficiency of the inductive-resonance energy transfer between the fluorescent probes and between the proteins and probes. The fluorescent probes used were 4-dimethyl-aminochalcone, 6-(2-anthroyl)-hexane acid and 7-(2-anthryl)-heptane acid. The lipids and proteins were found to occupy approximately equal areas on the LDL surface. The average area of the protein layer on the surface of one LDL particle made up to 480 +/- 60 nm2, the layer width was about 1 nm. The protein was rather evenly distributed on th surface of LDL particle without forming large (diameter much greater than 4 nm) plaques.
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PMID:[Surface of a human low-density plasma lipoprotein: areas occupied by proteins and lipids]. 706 18

The toxic effects of i.p. administered n-hexane and n-heptane on biochemical processes in rat liver, as indicated by the increase in alkaline phosphatase activity and decrease in FDP aldolase activity, and their reflection on blood chemistry, were studied. Serum cholinesterase activity and albumin and cholesterol content showed statistically significant decreases with the increase in FDP aldolase activity. The significance of the findings is discussed.
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PMID:Toxicity of n-hexane and n-heptane: some biochemical changes in liver and serum. 716 75

1. The anaesthetic effects of aqueous solutions of the n-alkanes pentane to nonane on the propagated action potential of squid axons have been investigated for a range of axon diameters. 2. By the use of small axons (approx. 200 microns diameter) to minimize effects due to long diffusion times and alkane depletion it was found that n-pentane and n-hexane caused a rapid reversible inhibition of the impulse, while higher homologues had progressively less effect, n-nonane being apparently inert. 3. The rate of action potential decline due to the n-alkanes was found to be strongly dependent on axon diameter. For n-hexane, n-heptane and n-octane the rate of decline was inversely proportional to the square of the axon diameter. 4. The mechanisms which may underly the increased sensitivity of small axons to impulse blockade by n-alkanes are discussed. A quantitative comparison is made between the effects of n-hexane, n-heptane and n-octane on the action potential. It is argued that this supports the idea of a real decline in anaesthetic potency on ascending the homologous series, rather than an effect due to long diffusion times and solution depletion.
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PMID:Nerve impulse blockage in squid axons by n-alkanes: the effect of axon diameter. 718 70

A high-performance liquid chromatographic method for the quantitative assay of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma is described. After addition of the internal standards, imipramine for clomipramine, desipramine for desmethylclomipramine and conversely, the compounds are extracted from blood or plasma at pH 10 into heptane containing 1% isoamyl alcohol; they are then back-extracted into an acidic aqueous phase and re-extracted at a basic pH into heptane. After evaporation, the residue is dissolved in 300 microliters of mobile phase and 150 microliters is injected. Both drugs and their mono-demethylated metabolites are well separated from the blood or plasma components and the other metabolites on a silica gel column using ethanol--hexane-dichloromethane-diethylamine (30:62:8:5 . 10(-3)) as the mobile phase at a flow-rate of 1.5 ml/min. The limit of sensitivity is 5 ng/ml for clomipramine and imipramine and 10 ng/ml for the corresponding mono-demethylated metabolites. This method has been used to analyse plasma from subjects given therapeutic doses of clomipramine or imipramine.
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PMID:Determination of clomipramine or imipramine and their mono-demethylated metabolites in human blood or plasma by high-performance liquid chromatography. 721 58

1. The electrical properties of squid giant axons were examined by means of admittance bridges at frequencies from 0.5 to 300 kHz. A simple equivalent circuit was used to estimate the membrane capacity. 2. The calculated membrane capacities decreased monotonically over the whole frequency range. 3. At 100 kHz and higher frequencies the membrane capacity was independent of potential. 4. At frequencies greater than 20 kHz, exposure of the axons to saturated or 0.9 saturated solutions of n-pentane (275-306 micrometer) reduced the capacity per unit area by 0.1-0.15 micro F cm-2. 5. At 1 kHz the effect of the saturated pentane solutions depended on the membrane potential. In axons having potentials between -60 and zero mV the pentane solutions lowered the capacity, whereas for potentials between -160 and -60 mV they produced little or no change. 6. Saturated solutions of n-hexane, n-heptane and n-octane exhibited qualitatively similar, but quantitatively smaller influences on the membrane capacity, the changes declining as the chain length increased. 7. Under voltage clamp, the peak inward and steady-state outward currents were partially suppressed by the hydrocarbons. Saturated solutions of n-pentane usually reduced the former (reversibly) by 60-80% and the latter by 20-40%. Solutions of n-hexane, n-heptane and n-octane appeared to have successively less effect. Except in deteriorating axons, none of the hydrocarbons produced any consistent changes in the passive membrane resistance, the resting potential or in the reversal potential of the transient inward current. 8. Both the changes in the clamp currents and in the membrane capacity were largely, though not usually completely, reversible. In the hydrocarbon solution the axons deteriorated more rapidly than normal. 9. The responses of axons of Doryteuthis plei to the hydrocarbons were very similar to those of Loligo forbesi with the exception that for the former all observed changes were some five times faster. 10. The time courses of the peak inward and steady-state outward currents on exposure of the axons to n-pentane resembled the time course of the change in membrane capacity at 100 kHz. 11. The simplest interpretation of the high frequency capacity results is suggested to be that, as for lipid bilayers, the membranes become thicker through adsorption of the hydrocarbon.
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PMID:Some effects of aliphatic hydrocarbons on the electrical capacity and ionic currents of the squid giant axon membrane. 725 65

Environmental sampling surveys have been conducted in ten large tire manufacturing plants across the U.S. to characterize the nature and intensity of current exposure to solvent vapors. These plants were chosen to represent a cross-section of the industry and include both old and new plants, plants of four different companies and plants with wide geographic distributions. A variety of organic solvents is used in the manufacture of tires and tubes; accordingly solvent vapors comprise one category of exposure for workers in specific Occupational Title Groups (OTGs). Approximately 1000 determinations of various solvent vapor components in air samples have been made with special emphasis on pentane, hexane, heptane, benzene and toluene vapor levels. Exposures stem from the widespread use of bulk materials including petroleum naphthas, gasoline and aliphatic and rubber solvents in various tire manufacturing operations.
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PMID:Worker exposures to chemical agents in the manufacture of rubber tires: solvent vapor studies. 739 32

The neurotoxicity of n-pentane, n-hexane, and n-heptane have been studied in Wistar strain male rats after exposure to 3000 ppm of n-pentane, n-hexane, or n-heptane for 12 hours a day for 16 weeks. The nerve conduction velocity and the distal latency were measured before the beginning of the exposure and after exposure for four, eight, 12, and 16 weeks. The experiment showed that n-hexane disturbed the conduction velocity of the motor nerve and the mixed nerve and prolonged the distal latency in the rat's tail, but that n-pentane and n-heptane did not. The light and electron microscopic examination showed that the peripheral nerve, the neuromuscular junction, and the muscle fibre of the rats exposed to n-hexane were severely impaired, but those of the rats exposed to n-pentane or n-heptane showed no particular changes even after 16 weeks of exposure. These results show that n-hexane is far more toxic to the peripheral nerve of the rat than n-pentane or n-heptane. It is necessary to study the neurotoxicity of other petroleum hydrocarbons, since some reports suggest that petroleum solvents might possibly contain neurotoxic hydrocarbons other than n-hexane.
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PMID:A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat. 742 74

Inhalation exposure of male rats at three dose levels (4.2, 21, 62 mol/L) to n-heptane vapor caused a dose-dependent brain and body solvent burden, which increased during two weeks of exposure. Initial neurochemical effects included reduced RNA concentration and increased NADPH-diaphorase in brain at the lowest dose. Increased proteolysis was detected in the cerebral samples in the second week at all doses, and the NADPH-diaphorase returned to the control range. Brain RNA content tended to be larger than in the controls. All biochemical effects were abolished after two weeks of withdrawal from the two-week exposure, with the exception of reduced glutathione at the lowest dose. None of the rats presented clinical signs of neuropathy, which indicates that heptane and its metabolites do not share the specific neurotoxicity of hexane and its metabolites.
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PMID:Neurochemical effects on rats of n-heptane inhalation exposure. 746 83

Polyneuropathy caused by n-hexane contained in glues was, until recently, the typical occupational disease of shoemakers. Glues no longer contain large concentrations of this solvent, and in some cases, it as been completely replaced by other hydrocarbons. The authors investigated the health status in a group of shoemakers using glues containing 35% technical heptane. The same glue, not containing n-hexane, was used by a shoemaker who worked at home; she developed an otherwise unexplainable peripheral polyneuropathy. For each of the 16 subjects, the following procedures were carried out: environmental sampling, biological monitoring for Mek and heptane metabolites, a neurological and electromyographic examination. No neurological abnormalities were found in the workers that could be attributable to occupational exposure, probably due to the low level environmental contamination (< 100 mg/m3 n-heptane) found in the 7 factories and workshops studied where acceptable hygiene conditions existed. The time course and ratio of urinary metabolites of heptane were also studied, the latter showing a predominance of 2- and 3- heptanol in the initial phase and 2-5 heptandione at the end of the work week; probably, the presence of other solvents, such as Mek, can modify the ratio of metabolites and consequently the formation of neurotoxic compounds could result.
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PMID:[Exposure to glues containing technical heptane: a clinical and electrophysiological study]. 773 10


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