Gene/Protein
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: CAS:107-59-5 (
tert-butyl chloroacetate
)
2
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using
tert-butyl chloroacetate
followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of
titanium
tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.
...
PMID:Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid. 1910 72
