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Query: CAS:1071-83-6 (Roundup)
1,244 document(s) hit in 27,025,112 MEDLINE articles (0.00 seconds)

Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus).
In Oreochromis niloticus that had been exposed for 3 months to sublethal concentrations (5 and 15 ppm) of the commercial glyphosate herbicide (C(3)H(8)NO(5)P) Roundup, the organs exhibited varying degrees of histopathological change. ... The structural damages could be correlated to the significant increase (p </= 0.05) in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities in the second and third months of exposure. ...
PMID:12900945 Environ. Toxicol. 2003 Aug 6

The effects of sub-chronic exposure of Wistar rats to the herbicide Glyphosate-Biocarb.
The object of this study was to analyze the hepatic effects of the herbicide Glyphosate-Biocarb (as commercialized in Brazil) in Wistar rats. ... Sub-chronic treatment of animals starting from the lowest dose of glyphosate induced the leakage of hepatic intracellular enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting irreversible damage in hepatocytes. ... We may conclude that Glyphosate-Biocarb may induce hepatic histological changes as well as AST and ALT leaking from liver to serum in experimental models.
PMID:15451553 Toxicol. Lett. 2004 Sep 29

The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup.
Roundup is a glyphosate-based herbicide that includes 78.5% glyphosate and surfactant at lower toxic concentrations. Glyphosate is an organophosphorated non-selective agrochemical widely used in many countries including Turkey and acts after the sprout in a systemic way. The objective of this study was to analyze toxic effects of the herbicide Roundup in rat liver. Animals were treated with 56mg/kg (p.o.) and 560mg/kg (p.o.) of Roundup (78% glyphosate+surfactant) each day, during 5 and 13 weeks. Hepatotoxicity was monitored by quantitative analysis of the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities and measured amount of serum lipoprotein (LDL, HDL), total cholesterol and creatinine were used as the biochemical markers of liver damages. ... Sub-chronic treatment, starting from the low and high doses of Roundup, it was observed that there were mild effects on activity of ALT, AST and LDH enzymes indicating the hepatic toxicity induced by Roundup. ...
PMID:21783836 Environ. Toxicol. Pharmacol. 2007 Sep 8

Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate.
Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated with sub-lethal concentration of Roundup (269.9mg/kg) or glyphosate (134.95mg/kg) each 2 days, during 2 weeks. Hepatotoxicity was monitored by quantitative analysis of the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities, total protein, albumin, triglyceride and cholesterol. ... The second aim of this study to investigate how glyphosate alone or included in herbicide Roundup affected hepatic reduced glutathione (GSH) and lipid peroxidation (LPO) levels of animals as an index of antioxidant status and oxidative stress, respectively, as well as the serum nitric oxide (NO) and alpha tumour necrosis factor (TNF-?) were measured. Treatment of animals with Roundup induced the leakage of hepatic intracellular enzymes, ALT, AST and ALP suggesting irreversible damage in hepatocytes starting from the first week. It was found that the effects were different on the enzymes in Roundup and glyphosate-treated groups. Significant time-dependent depletion of GSH levels and induction of oxidative stress in liver by the elevated levels of LPO, further confirmed the potential of Roundup to induce oxidative stress in hepatic tissue. However, glyphosate caused significant increases in NO levels more than Roundup after 2 weeks of treatment. ... The results suggest that excessive antioxidant disruptor and oxidative stress is induced with Roundup than glyphosate.
PMID:21784030 Environ. Toxicol. Pharmacol. 2009 Jun 18

Protective effect of Ginkgo biloba L. leaf extract against glyphosate toxicity in Swiss albino mice.
The aim of the present study was to investigate the protective role of Ginkgo biloba L. leaf extract against the active agent of Roundup(R) herbicide (Monsanto, Creve Coeur, MO, USA). ... Animals from all the groups were sacrificed at the end of 72 hours, and their blood, bone marrow, and liver and kidney tissues were analyzed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and glutathione (GSH) levels and the presence of micronucleus (MN), chromosomal aberrations (CAs), and pathological damages. The results indicated that serum AST, ALT, BUN, and creatinine levels significantly increased in mice treated with glyphosate alone compared with the other groups (P<.05). ...
PMID:21859351 J Med Food 2011 Aug 22

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup((R)).
We evaluated the toxicity of hepatic, hematological, and oxidative effects of glyphosate-Roundup((R)) on male and female albino Swiss mice. ... Hepatotoxicity was monitored by quantitative analysis of the serum enzymes ALT, AST, and ?-GT and renal toxicity by urea and creatinine. ... Significant increases in the levels of hepatic enzymes (ALT, AST, and ?-GT) were observed for both herbicide treatments, but no considerable differences were found by histological analysis. ... The results of this study indicate that glyphosate-Roundup((R)) can promote hematological and hepatic alterations, even at subacute exposure, which could be related to the induction of reactive oxygen species.
PMID:23554553 Interdiscip Toxicol 2013 Apr 5

Effect of a glyphosate-based herbicide in Cyprinus carpio: assessment of acetylcholinesterase activity, hematological responses and serum biochemical parameters.
The objective of this study was to investigate the toxicity effects of acute and sublethal of Roundup(R) as a glyphosate-based herbicide on acetylcholinesterase (AChE) activity and several hematological and biochemical parameters of Cyprinus carpio. The LC??-96 h of Roundup(R) to C. carpio was found to be 22.19 ppm. Common carp was subjected to Roundup(R) at 0 (control), 3.5, 7 and 14 ppm for 16 days, and the AChE activity is verified in tissues of gill, muscle, brain and liver. ... Also, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) in Roundup(R) treated groups were significantly higher than the controlled group at experimental periods. ... It seems that the changes in hematological and biochemical parameters as well as AChE activity could be used as efficient biomarkers in order to determine Roundup(R) toxicity in aquatic environment.
PMID:24075644 Ecotoxicol. Environ. Saf. 2013 Sep 26

Metabolic and behavior changes in surubim acutely exposed to a glyphosate-based herbicide.
This study examined the effect of glyphosate-based herbicide (Roundup Original), the major herbicide used in soybean crops in Mato Grosso state, at concentrations of 0, 2.25, 4.5, 7.5, and 15 mg L(-1) on metabolic and behavior parameters of the hybrid fish surubim in an acute exposure lasting 96 h. ... Plasma levels of cholesterol, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were also determined. ... Plasma ALT increased, and no alterations were recorded for AST levels. ...
PMID:25147081 Arch. Environ. Contam. Toxicol. 2014 Aug 22

Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup.
... In 2011, we demonstrated that hepatic cell mortality induced by environmentally realistic levels of the widely used herbicide Roundup (R) in vitro can be almost entirely prevented by plant extracts called Dig1 (D, Digeodren). ... Proteins, creatinine, urea, phosphate, potassium, sodium, calcium, chloride ions, testosterone, estradiol, AST and ALT were measured in serum. ... D, without any side effect observable in these conditions, presented strong preventive and therapeutic properties in vivo after a short-term intoxication by the widely used pesticide Roundup.
PMID:27450510 BMC Complement Altern Med 2016 Jul 22

In vitro cytotoxicity assessment of roundup (glyphosate) in L-02 hepatocytes.
The goal of the present study was to elucidate the in vitro cytotoxicity of Roundup and to reveal the possible related mechanisms in L-02 hepatocytes. By detecting reactive oxygen species (ROS) production, glutathione (GSH)/superoxide dismutase (SOD) levels, mitochondrial permeability transition pore (PTP) open rate, apoptosis-inducing factor (AIF) release, intracellular Ca2+ concentration, and alanine aminotransferease (ALT)/aspartate aminotransferase (AST) leakage, we determined that Roundup induced anti-oxidant system inhibition, mitochondria damage, DNA damage, membrane integrity and permeability changes, and apoptosis in L-02 hepatocytes. By revealing the mechanistic insights of Roundup-induced cytotoxicity, our results are valuable for the design of preventive and therapeutic strategies for the occupational population exposed to Roundup and other pesticides.
PMID:28281894 J Environ Sci Health B 2017 Mar 10

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