Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:1921-70-6 (Pristane)
182 document(s) hit in 27,025,112 MEDLINE articles (0.00 seconds)

Distinctive patterns of autoimmune response induced by different types of mineral oil.
Although mineral oils are generally considered nontoxic and have a long history of use in humans, the mineral oil Bayol F (incomplete Freund's adjuvant, IFA) and certain mineral oil components (squalene and n-hexadecane) induce lupus-related anti-nRNP/Sm or -Su autoantibodies in nonautoimmune mice. ... Pristane and n-hexadecane were found in IFA (0.17% and 0.10% w/v, respectively) and MOs (0.0026-0.027%). ...
PMID:14718649 Toxicol. Sci. 2004 Jan 12

Pristane-induced autoimmunity in germ-free mice.
... Thus, bacterial stimulation was not required for lupus autoantibodies, peritoneal granuloma formation, hypergammaglobulinemia, or cytokine overproduction. ...
PMID:15639644 Clin. Immunol. 2005 Jan 11

Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
... Pristane-treated granzyme B-deficient mice also produced antibodies directed against the U1-70-kd antigen, a previously identified granzyme B substrate. ...
PMID:15934098 Arthritis Rheum. 2005 Jun 4

Hypercatabolism of IgG in mice with lupus-like syndrome.
The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. ...
PMID:16038110 Lupus 2005 Jul 26

Induction of apoptosis by the hydrocarbon oil pristane: implications for pristane-induced lupus.
Intraperitoneal injection of the hydrocarbon oil pristane into normal mice leads to a lupus-like autoimmune syndrome. ... Pristane arrests cell growth and induces cell death by apoptosis via the mitochondrial pathway of caspase activation in a dose-dependent manner. ... These findings suggest that apoptosis may be a critical initial event in the pathogenesis of pristane-induced lupus and are of potential relevance for human systemic lupus erythematosus.
PMID:16177126 J. Immunol. 2005 Sep 24

Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study.
... Pristane house dust among the exposed homes was higher than in the comparison communities. ... The prevalence of rheumatic diseases (OR = 10.78; CI = 4.14, 28.12) and lupus (OR = 19.33; CI = 1.96, 190.72) was greater in the exposed population compared to the unexposed. ...
PMID:17316448 Environ Health 2007 Feb 22

Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus.
Pristane-induced lupus is a well-established model of murine lupus. Mice injected with Pristane develop lupus-specific autoantibodies and glomerulonephritis. A chance observation led us to identify and characterize haemorrhagic pulmonary capillaritis in Pristane-injected mice. Eight-week-old C57Bl/10 (B10, H-2(b)) mice received a single intraperitoneal injection of 0.5 ml of Pristane. ... Mice were bled at 2 weeks after Pristane injection and monthly thereafter for serology and for antinuclear antibody (ANA). ... All mice injected with Pristane developed a pulmonary capillaritis with perivascular infiltration with macrophages, neutrophils, lymphocytes and eosinophils. ... Kidneys demonstrated an increase in mesangial matrix and cellularity compatible with WHO Class II lupus lesion. ...
PMID:17576695 Rheumatology (Oxford) 2007 Jun 18

Deficiency of the type I interferon receptor protects mice from experimental lupus.
Systemic lupus erythematosus (SLE) is diagnosed according to a spectrum of clinical manifestations and autoantibodies associated with abnormal expression of type I interferon (IFN-I)-stimulated genes (ISGs). The role of IFN-I in the pathogenesis of SLE remains uncertain, partly due to the lack of suitable animal models. The objective of this study was to examine the role of IFN-I signaling in the pathogenesis of murine lupus induced by 2,6,10,14-tetramethylpentadecane (TMPD). ... TMPD did not induce lupus-specific autoantibodies (anti-RNP, anti-Sm, anti-double-stranded DNA) in IFNAR(-/-) mice, whereas 129Sv controls developed these specificities. ... The clinical and serologic manifestations observed in TMPD-treated mice were strongly dependent on IFNAR signaling, which is consistent with the association of increased expression of ISGs with lupus-specific autoantibodies and nephritis in humans. Similar to its proposed role in human SLE, signaling via the IFNAR is central to the pathogenesis of autoantibodies and glomerulonephritis in TMPD-induced lupus. This lupus model is the first animal model shown to recapitulate the "interferon signature" in peripheral blood.
PMID:17968932 Arthritis Rheum. 2007 Oct 31

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.
Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for dysregulated IFN-I production in SLE remain unclear, autoantibody-mediated uptake of endogenous nucleic acids is thought to play a role. 2,6,10,14-tetramethylpentadecane (TMPD; also known as pristane) induces a lupus-like disease in mice characterized by immune complex nephritis with autoantibodies to DNA and ribonucleoproteins. We recently reported that TMPD also causes increased ISG expression and that the development of the lupus is completely dependent on IFN-I signaling (Nacionales, D.C., K.M. ...
PMID:19047436 J. Exp. Med. 2008 Dec 1

B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.
Intraperitoneal exposure of nonautoimmune mice to 2,6,10,14-tetramethylpentadecane (TMPD) causes lupus and the formation of ectopic lymphoid tissue. ...
PMID:19299721 J. Immunol. 2009 Mar 21


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