Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: CAS:537-46-2 (Methamphetamine)
 2,465 document(s) hit in 27,025,112 MEDLINE articles (0.00 seconds)

Methamphetamine self-administration reduces alcohol consumption and preference in alcohol-preferring P rats.
 ... Male alcohol-preferring P rats had continuous access to a two-bottle alcohol drinking procedure in the home cage. ...
PMID:27860181 Addict Biol 2016 Nov 16

Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats.
 ... Between tests, the rats underwent either voluntary abstinence (achieved via a discrete choice procedure between drug and palatable food; 20 trials/day) or home-cage forced abstinence. ...
PMID:28025975 Neuropsychopharmacology 2016 Dec 27

Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory.
 ... We assessed the effects of MA (4 x 10 mg/kg at 2 h intervals) in combination with prior barren-cage housing in adult male Sprague-Dawley rats on monoamines and glial fibrillary acid protein (GFAP) in one cohort and spatial learning and memory in the Morris water maze in another cohort. ... In neostriatum, barren-cage housing protected against MA-induced increases in GFAP, but it did not prevent DA and 5-HT reductions, although it did increase hippocampal norepinephrine. ... Barren-cage housing enhanced performance during acquisition but not during reversal or shift or on probe trials. The data indicate that prior barren-cage housing moderates MA-induced neostriatal astrogliosis and initial spatial learning, but has no protective effect when the platform is smaller and relocated and therefore requires cognitive flexibility in relearning.
PMID:28287691 ACS Chem Neurosci 2017 Mar 27

GABAA receptor positive allosteric modulators modify the abuse-related behavioral and neurochemical effects of methamphetamine in rhesus monkeys.
 ... Methamphetamine self-administration (0.03 mg/kg/inf) was evaluated during morning sessions. Methamphetamine-induced dopamine overflow was assessed through in vivo microdialysis targeting the nucleus accumbens. ... Acute pretreatment with a low dose of temazepam before self-administration sessions increased methamphetamine self-administration without affecting normal daytime home-cage activity. ...
PMID:28495376 Neuropharmacology 2017 May 8

Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol.
 ... In this study, we investigated the reinstatement of METH using conditioned place preference (CPP) in male alcohol-preferring (P) rats exposed to home-cage free choice ethanol drinking. ...
PMID:30471010 J. Mol. Neurosci. 2018 Nov 23


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